{{Rsnum
|rsid=17337252
|Gene=RB1CC1
|Chromosome=8
|position=52674146
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.4527
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=RB1CC1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 11.5 | 58.4 | 30.1
| HCB | 0.7 | 25.5 | 73.7
| JPT | 0.0 | 35.4 | 64.6
| YRI | 74.8 | 25.2 | 0.0
| ASW | 52.6 | 33.3 | 14.0
| CHB | 0.7 | 25.5 | 73.7
| CHD | 2.8 | 29.4 | 67.9
| GIH | 36.6 | 42.6 | 20.8
| LWK | 53.6 | 40.9 | 5.5
| MEX | 8.8 | 50.9 | 40.4
| MKK | 66.0 | 29.5 | 4.5
| TSI | 24.5 | 49.0 | 26.5
| HapMapRevision=28
}}{{Venter SNP
|rsid=17337252
|allele=G
|frequency=0.425
|uid=1103652319289
|type=heterozygous_SNP
|hugo=RB1CC1
|ensembl gene=ENSG00000023287
|ensembl transcript=ENST00000025008
|sift=TOLERATED
|disease=Defects in RB1CC1 are probably involved in the tumorigenesis of breast cancer. 20% (7 of 35) of primary breast cancers examined contain mutations in RB1CC1, including nine large interstitial deletions predicted to yield markedly truncated RB1CC1 proteins. RB1CC1 is frequently mutated in breast cancer and shows characteristics of a classical tumor suppressor gene.
}}

{{GET Evidence
|gene=RB1CC1
|aa_change=Met234Thr
|aa_change_short=M234T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17337252
|overall_frequency_n=4371
|overall_frequency_d=10758
|overall_frequency=0.406302
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.001
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}