{{Rsnum
|rsid=1734787
|Gene=MECP2
|Chromosome=X
|position=154059995
|Orientation=plus
|GMAF=0.3398
|Gene_s=MeCP2,MECP2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 75.2 | 9.7 | 15.0
| HCB | 4.4 | 24.8 | 70.8
| JPT | 18.6 | 15.9 | 65.5
| YRI | 87.1 | 9.5 | 3.4
| ASW | 86.0 | 14.0 | 0.0
| CHB | 4.4 | 24.8 | 70.8
| CHD | 7.3 | 15.6 | 77.1
| GIH | 32.7 | 17.8 | 49.5
| LWK | 89.1 | 6.4 | 4.5
| MEX | 50.0 | 27.6 | 22.4
| MKK | 67.3 | 16.7 | 16.0
| TSI | 69.6 | 21.6 | 8.8
| HapMapRevision=28
}}[[rs1734787]] is one of several SNPs in the methyl CpG binding protein 2 ([[MECP2]]) that have been associated with risk for systemic [[lupus]] erythromatosis (SLE). The [[MECP2]] gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease.

An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the [[rs1734787]](C) risk allele of 1.42 (CI: 1.26â€“1.60, p = 1.6Ã—10e-08).{{PMID|18320046|OA=1
}}

{{PMID Auto
|PMID=19333917
|Title=Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}