{{Rsnum
|rsid=1734791
|Gene=MECP2
|Chromosome=X
|position=154065469
|Orientation=plus
|GMAF=0.3851
|Gene_s=MeCP2,MECP2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 74.1 | 9.8 | 16.1
| HCB | 4.4 | 25.5 | 70.1
| JPT | 17.7 | 16.8 | 65.5
| YRI | 56.6 | 23.4 | 20.0
| ASW | 66.7 | 29.8 | 3.5
| CHB | 4.4 | 25.5 | 70.1
| CHD | 9.2 | 16.5 | 74.3
| GIH | 35.0 | 20.0 | 45.0
| LWK | 66.1 | 19.3 | 14.7
| MEX | 48.3 | 29.3 | 22.4
| MKK | 49.7 | 24.5 | 25.8
| TSI | 69.7 | 21.2 | 9.1
| HapMapRevision=28
}}[[rs1734791]] is one of several SNPs in the methyl CpG binding protein 2 ([[MECP2]]) that have been associated with risk for systemic [[lupus]] erythromatosis (SLE). The [[MECP2]] gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease.

An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the [[rs1734791]](A) risk allele of 1.39 (CI: 1.24â€“1.57, p = 7.2Ã—10-08).{{PMID|18320046|OA=1
}}

{{PMID|19333917|OA=1
}} Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.

{{PMID|19717458|OA=1
}} A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}