{{Rsnum
|rsid=1736557
|Gene=FMO3
|Chromosome=1
|position=171110939
|Orientation=plus
|GMAF=0.09412
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FMO3
}}[[rs1736557]], also known as Val257Met, is a SNP in the [[FMO3]] gene. It has been linked to [[trimethylaminuria]]; see variant .0002, [http://omim.org/entry/136132#0001 OMIM 136132].

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 14.2 | 85.8
| HCB | 7.3 | 35.8 | 56.9
| JPT | 1.8 | 24.8 | 73.5
| YRI | 0.0 | 4.1 | 95.9
| ASW | 0.0 | 7.0 | 93.0
| CHB | 7.3 | 35.8 | 56.9
| CHD | 2.8 | 39.4 | 57.8
| GIH | 2.0 | 15.8 | 82.2
| LWK | 0.0 | 5.5 | 94.5
| MEX | 0.0 | 12.1 | 87.9
| MKK | 0.0 | 9.6 | 90.4
| TSI | 0.0 | 11.8 | 88.2
| HapMapRevision=28
}}

{{omim
|id=136132
|rsnum=1736557
|variant=0002
}}

{{ClinVar
|rsid=1736557
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=171110939
|CHROM=1
|GMAF=0.0939
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050178000a05150517110101
|GENEINFO=FMO3:2328
|GENE_NAME=FMO3
|GENE_ID=2328
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.171110939G>A
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NM_001002294.2:c.769G>A; 136132.0002
|CLNSIG=5
|CLNCUI=C0342739
|CLNDBN=Trimethylaminuria
|Disease=Trimethylaminuria
|CLNACC=RCV000017698.26
|Tags=PM;TPA;PMC;SLO;NSM;REF;ASP;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9059; 0.09412
|CLNDSDB=GeneReviews:MedGen:OMIM:SNOMED_CT
|CLNDSDBID=NBK1103:C0342739:602079:237959005
|COMMON=1
}}

{{PMID Auto
|PMID=15858076
|Title=Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants.
|OA=1
}}

{{GET Evidence
|gene=FMO3
|aa_change=Val257Met
|aa_change_short=V257M
|impact=benign
|qualified_impact=Low clinical importance, Uncertain benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1736557
|overall_frequency_n=614
|overall_frequency_d=10758
|overall_frequency=0.0570738
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|qualityscore_case_control=1
|qualitycomment_case_control=Y
|qualityscore_familial=0
|gene_in_genetests=Y
|in_omim=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=0
|autoscore=4
|webscore=N
|n_web_uneval=9
|variant_evidence=0
|clinical_importance=0
|summary_short=This common variant (HapMap allele frequency of 9.2%) appears to have no functional effect. OMIM has recorded it as having been seen homozygously in an individual with Trimethylaminuria, but Treacy et al. 1998 conclude it is a polymorphism.
}}

{{PMID Auto
|PMID=24165757
|Title=The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}