{{Rsnum
|rsid=17367504
|Gene=MTHFR
|Chromosome=1
|position=11802721
|Orientation=plus
|GMAF=0.1097
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MTHFR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 69.0 | 28.3 | 2.7
| HCB | 84.7 | 14.6 | 0.7
| JPT | 77.9 | 21.2 | 0.9
| YRI | 82.2 | 17.8 | 0.0
| ASW | 71.9 | 28.1 | 0.0
| CHB | 84.7 | 14.6 | 0.7
| CHD | 81.5 | 16.7 | 1.9
| GIH | 71.3 | 25.7 | 3.0
| LWK | 80.9 | 18.2 | 0.9
| MEX | 87.9 | 12.1 | 0.0
| MKK | 82.1 | 17.9 | 0.0
| TSI | 83.3 | 14.7 | 2.0
| HapMapRevision=28
}}

Each G allele is associated with 0.89 x odds of high blood pressure, according to 23andMe. {{PMID|19430483|OA=1
}}

[http://blog.23andme.com/2009/05/12/snpwatch-researchers-find-more-genetic-variations-associated-with-blood-pressure/ 23andMe blog] [[blood pressure]]

{{PMID Auto GWAS
|PMID=19430483
|Trait=Systolic blood pressure
|Title=Genome-wide association study identifies eight loci associated with blood pressure
|RiskAllele=G
|Pval=2E-13
|OR=0.85
|ORtxt=[0.63-1.07] mm Hg decrease
|OA=1
}}

{{PMID Auto GWAS
|PMID=21909110
|Trait=None
|Title=Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
|RiskAllele=G
|Pval=2E-16
|OR=0.5340
|ORtxt=[0.40-0.66] mmHg decrease
|OA=1
}}

{{PMID Auto
|PMID=19944404
|Title=Genomic dissection of population substructure of Han Chinese and its implication in association studies.
|OA=1
}}

{{PMID Auto
|PMID=20031578
|Title=Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20852445
|Title=Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
}}

{{PMID Auto
|PMID=22504314
|Title=Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.
|OA=1
}}

{{PMID Auto
|PMID=22525200
|Title=Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17367504
|overall_frequency_n=8
|overall_frequency_d=128
|overall_frequency=0.0625
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

[[High Blood Pressure (Hypertension)]]

{{PMID Auto
|PMID=22959498
|Title=Recapitulation of four hypertension susceptibility genes (CSK, CYP17A1, MTHFR, and FGF5) in East Asians.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}