{{Rsnum
|rsid=1738074
|Gene=TAGAP
|Chromosome=6
|position=159044945
|Orientation=minus
|GMAF=0.4412
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TAGAP
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 24.8 | 43.4 | 31.9
| HCB | 47.4 | 37.8 | 14.8
| JPT | 47.3 | 41.1 | 11.6
| YRI | 49.7 | 39.5 | 10.9
| ASW | 61.4 | 35.1 | 3.5
| CHB | 47.4 | 37.8 | 14.8
| CHD | 24.3 | 46.7 | 29.0
| GIH | 17.8 | 48.5 | 33.7
| LWK | 37.3 | 51.8 | 10.9
| MEX | 34.5 | 39.7 | 25.9
| MKK | 38.1 | 48.4 | 13.5
| TSI | 15.7 | 51.0 | 33.3
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs1738074
|PubMedID=18311140
|Condition=Celiac disease
|Gene=TAGAP
|Risk Allele=A
|pValue=7.00E-008
|OR=1.21
|95CI=1.13-1.30
|OA=1
}}

{{omim
|desc=DIABETES MELLITUS, INSULIN-DEPENDENT, 21; IDDM21
|id=612521
|rsnum=1738074
}}

{{omim
|desc=DIABETES MELLITUS, INSULIN-DEPENDENT; IDDM
|id=222100
|rsnum=1738074
}}

{{omim
|desc=CELIAC DISEASE, SUSCEPTIBILITY TO, 12; CELIAC12
|id=612010
|rsnum=1738074
}}
{{PMID Auto
|PMID=19693089
|Title=Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort
}}

{{PharmGKB
|RSID=rs1738074
|Name_s=
|Gene_s=TAGAP
|Feature=
|Evidence=PubMed ID:18311140; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Newly identified genetic risk variants for celiac disease related to the immune response (Initial Sample Size: 767 cases, 1,422 controls; Replication Sample Size: 1,643 cases, 3,406 controls; Risk Allele: rs1738074-A).
|Drugs=
|Drug Classes=
|Diseases=Celiac Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356754
}}

{{PMID Auto GWAS
|PMID=20190752
|Trait=Celiac disease
|Title=Multiple common variants for celiac disease influencing immune gene expression
|RiskAllele=A
|Pval=3E-15
|OR=1.16
|ORtxt=[1.12-1.21]
|OA=1
}}

{{PMID Auto GWAS
|PMID=22190364
|Trait=None
|Title=Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|RiskAllele=C
|Pval=4E-7
|OR=1.1500
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
|PMID=21833088
|Trait=None
|Title=Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|RiskAllele=G
|Pval=7E-15
|OR=1.1300
|ORtxt=[1.12-1.15]
|OA=1
}}

{{PMID Auto
|PMID=22087237
|Title=Improving the estimation of celiac disease sibling risk by non-HLA genes
|OA=1
}}

{{PMID Auto
|PMID=22127930
|Title=Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans
|OA=1
}}

{{PMID|18713140|OA=1
}} Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.

{{PMID|18853133|OA=1
}} Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

{{PMID|19073967|OA=1
}} Shared and distinct genetic variants in type 1 diabetes and celiac disease.

{{PMID|21383967|OA=1
}} Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

{{PMID|21390051|OA=1
}} Fine mapping the TAGAP risk locus in rheumatoid arthritis.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1738074
|overall_frequency_n=59
|overall_frequency_d=128
|overall_frequency=0.460938
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=52
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22592522
|Title=Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}