{{Rsnum
|rsid=17388568
|Gene=ADAD1
|Chromosome=4
|position=122408207
|Orientation=plus
|GMAF=0.1726
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ADAD1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 9.7 | 49.6 | 40.7
| HCB | 1.5 | 25.5 | 73.0
| JPT | 0.0 | 21.2 | 78.8
| YRI | 0.0 | 1.4 | 98.6
| ASW | 0.0 | 5.3 | 94.7
| CHB | 1.5 | 25.5 | 73.0
| CHD | 0.9 | 22.9 | 76.1
| GIH | 2.0 | 26.3 | 71.7
| LWK | 0.0 | 10.9 | 89.1
| MEX | 1.7 | 22.4 | 75.9
| MKK | 2.6 | 26.3 | 71.2
| TSI | 4.9 | 37.3 | 57.8
| HapMapRevision=28
}}
[[rs17388568]] has been reported in a large study to be associated with [[type-1 diabetes]].

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.26 (CI 1.11-1.42), and for homozygotes, 1.58 (CI 1.27-1.95). {{PMID|17554300|OA=1
}}

In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.11 (CI 1.05â€“1.18). {{PMID|17554260|OA=1
}}

{{GWAS Summary
|SNP=rs17388568
|PubMedID=17554300
|Condition=Type 1 diabetes
|Gene=NR
|Risk Allele=A
|pValue=3.00E-006
|OR=1.26
|95CI=1.11-1.42
|OA=1
}}

{{omim
|desc=DIABETES MELLITUS, INSULIN-DEPENDENT, 23; IDDM23
|id=612622
|rsnum=17388568
}}

{{omim
|desc=DIABETES MELLITUS, INSULIN-DEPENDENT; IDDM
|id=222100
|rsnum=17388568
}}

{{PharmGKB
|RSID=rs17388568
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,963 cases, 2,938 controls; Replication Sample Size: (see Todd 2007); Risk Allele: rs17388568-A). This variant is associated with type 1 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 1
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356644
}}

{{PMID Auto
|PMID=20184734
|Title=The 4q27 locus and familial prostate cancer risk
|OA=1
}}

{{PMID Auto
|PMID=20553587
|Title=Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
|OA=1
}}

{{PMID Auto GWAS
|PMID=21297633
|Trait=None
|Title=Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
|RiskAllele=A
|Pval=9E-7
|OR=1.1200
|ORtxt=[1.07-1.17]
|OA=1
}}

{{PMID Auto GWAS
|PMID=21829393
|Trait=None
|Title=Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|RiskAllele=A
|Pval=0.000006
|OR=1.1000
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=18369459
|Title=A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
|OA=1
}}

{{PMID Auto
|PMID=19140132
|Title=Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
|OA=1
}}

{{PMID Auto
|PMID=19201773
|Title=Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
|OA=1
}}

{{PMID Auto
|PMID=19359276
|Title=Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
|OA=1
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=20722033
|Title=The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
|OA=1
}}

{{PMID Auto
|PMID=21875375
|Title=Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17388568
|overall_frequency_n=23
|overall_frequency_d=128
|overall_frequency=0.179688
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23817569
  |Trait=Self-reported allergy
  |Title=A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
  |RiskAllele=A
  |Pval=4E-8
  |OR=.07
  |ORtxt=[0.047-0.099] unit increase
  |OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}