{{Rsnum
|rsid=17435
|Gene=MECP2
|Chromosome=X
|position=154046529
|Orientation=plus
|GMAF=0.4825
|Gene_s=MECP2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 68.8 | 13.4 | 17.9
| HCB | 6.6 | 24.3 | 69.1
| JPT | 18.0 | 18.9 | 63.1
| YRI | 23.6 | 18.8 | 57.6
| ASW | 35.1 | 35.1 | 29.8
| CHB | 6.6 | 24.3 | 69.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 32.7 | 21.4 | 45.9
| LWK | 33.0 | 29.4 | 37.6
| MEX | 43.1 | 29.3 | 27.6
| MKK | 34.8 | 28.4 | 36.8
| TSI | 63.6 | 23.2 | 13.1
| HapMapRevision=28
}}
[[rs17435]] is one of several SNPs in the methyl CpG binding protein 2 ([[MECP2]]) that have been associated with risk for systemic [[lupus]] erythromatosis (SLE). The [[MECP2]] gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease.

An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the [[rs17435]](T) risk allele of 1.39 (CI: 1.24â€“1.56, p = 1.2Ã—10e-08).{{PMID|18320046|OA=1
}}

{{PMID Auto
|PMID=19714582
|Title=Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors
}}

{{omim
|id=300809
|rsnum=17435
}}

{{PMID|19333917|OA=1
}} Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.

{{PMID|19442287|OA=1
}} Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.

{{PMID|19717458|OA=1
}} A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.

{{PMID Auto
|PMID=23444193
|Title=New insight on the Xq28 association with systemic sclerosis
}}

{{PMID Auto
|PMID=24709033
|Title=Analysis of two autoimmunity genes, IRAK1 and MECP2, in giant cell arteritis
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}