{{Rsnum
|rsid=17445836
|Chromosome=16
|position=85984057
|Orientation=plus
|GMAF=0.1281
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 7.9 | 39.7 | 52.4
| HCB | 0.0 | 18.2 | 81.8
| JPT | 0.0 | 13.3 | 86.7
| YRI | 0.0 | 1.6 | 98.4
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 18.2 | 81.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs17445836]] is a SNP in the region of the [[IRF8]] gene.

A large study (~5,000 patients) found an increased risk for [[multiple sclerosis]] associated with [[rs17445836]]; the odds ratio for the minor allele was reported as 0.80 (CI: 0.72-0.89, p=3.73x10(-9)).{{doi|10.1038/ng.401}}

{{PMID Auto GWAS
|PMID=19525953
|Trait=Multiple sclerosis
|Title=Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
|RiskAllele=G
|Pval=4E-9
|OR=1.25
|ORtxt=[1.12-1.39]
|OA=1
}}

{{omim
|id=126200
|rsnum=17445836
}}

{{PMID Auto
|PMID=20405052
|Title=The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17445836
|overall_frequency_n=17
|overall_frequency_d=128
|overall_frequency=0.132812
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23965942
|Title=Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}