{{Rsnum
|rsid=174537
|Gene=MYRF
|Chromosome=11
|position=61785208
|Orientation=plus
|GMAF=0.3329
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=MYRF
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 43.4 | 44.2 | 12.4
| HCB | 40.1 | 44.5 | 15.3
| JPT | 46.9 | 42.5 | 10.6
| YRI | 97.3 | 2.7 | 0.0
| ASW | 84.2 | 15.8 | 0.0
| CHB | 40.1 | 44.5 | 15.3
| CHD | 28.7 | 42.6 | 28.7
| GIH | 79.2 | 20.8 | 0.0
| LWK | 94.5 | 5.5 | 0.0
| MEX | 12.1 | 44.8 | 43.1
| MKK | 84.6 | 14.7 | 0.6
| TSI | 58.8 | 32.4 | 8.8
| HapMapRevision=28
}}[[rs174537]] is a SNP near the [[FADS1]] gene on chromosome 11. The [[FADS1]] gene is one of 3 fatty acid desaturases in this region; higher polyunsaturated fatty acids (PUFA) levels are generally correlated with lower risk for [[heart disease]].

A study of 1,075 participants in the InCHIANTI study on aging concluded that [[rs174537]](T;T) individuals had lower arachidonic acid (AA), as well as lower levels of all other polyunsaturates measured (excepting linoleic acid, which followed the opposite pattern, and alpha-linoleic acid), compared to (G;G) homozgyotes (p = 6 x 10e-46), and that this one SNP accounted for almost 19% of the variance in AA levels. Individuals carrying at least one [[rs174537]](G) allele had higher low-density lipoprotein (LDL-C) and total cholesterol levels. This effect of [[rs174537]] was confirmed in an independent sample of 1,076 participants in the GOLDN study.{{PMID|19148276|OA=1
}}

{{omim
|desc=POLYUNSATURATED FATTY ACIDS PLASMA LEVEL QUANTITATIVE TRAIT LOCUS
|id=612795
|rsnum=174537
}}

{{PMID|19060910|OA=1
}} Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

{{PMID|19798445|OA=1
}} Genetic determinants of circulating sphingolipid concentrations in European populations.

{{PMID|20562440|OA=1
}} FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

{{PMID|20565855|OA=1
}} Genetic variation in lipid desaturases and its impact on the development of human disease.

{{PMID|21040914}} FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.

{{PMID|21115529|OA=1
}} Genetics and genomics of human ageing.

{{PMID|21383846|OA=1
}} Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.

{{PMID Auto
|PMID=23285256
|Title=Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism
|OA=1
}}

{{PMID Auto
|PMID=23160180
|Title=Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement.
|OA=1
}}

{{PMID Auto
|PMID=24962583
|Title=Relationship between a Common Variants in the Fatty Acid Desaturase (FADS) Cluster and Eicosanoid Generation in Humans
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}