{{Rsnum
|rsid=174546
|Gene=FADS1
|Chromosome=11
|position=61802358
|Orientation=plus
|GMAF=0.3297
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FADS1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 44.2 | 43.4 | 12.4
| HCB | 40.1 | 44.5 | 15.3
| JPT | 46.9 | 42.5 | 10.6
| YRI | 98.0 | 2.0 | 0.0
| ASW | 84.2 | 15.8 | 0.0
| CHB | 40.1 | 44.5 | 15.3
| CHD | 28.4 | 42.2 | 29.4
| GIH | 82.2 | 17.8 | 0.0
| LWK | 96.4 | 3.6 | 0.0
| MEX | 13.8 | 43.1 | 43.1
| MKK | 86.5 | 12.8 | 0.6
| TSI | 58.8 | 33.3 | 7.8
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060910
|Trait=LDL cholesterol
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
|RiskAllele=G
|Pval=1E-7
|OR=0.96
|ORtxt=[0.06-0.13] mmol/l decrease
|OA=1
}}

{{PharmGKB
|RSID=rs174546
|Name_s=
|Gene_s=C11orf10, FADS1
|Feature=
|Evidence=PubMed ID:19060910; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (Initial Sample Size: 4,763 individuals; Replication Sample Size: NR); (Region: 11q12.2; Reported Gene(s): FADS1, FADS2; Risk Allele: rs174546-G); (p-value= 0.0000001).This variant is associated with LDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740281
}}

{{PMID Auto
|PMID=20484448
|Title=Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study
}}
{{PMID Auto GWAS
|PMID=20694148
|Trait=None
|Title=A genome-wide association study of the metabolic syndrome in Indian Asian men
|RiskAllele=A
|Pval=6E-7
|OR=0.03
|ORtxt=[0.02-0.04] mmol/l decrease
|OA=1
}}

{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=T
|Pval=5E-24
|OR=3.8200
|ORtxt=None
|OA=1
}}

{{PMID|19148276|OA=1
}} Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.

{{PMID|19798445|OA=1
}} Genetic determinants of circulating sphingolipid concentrations in European populations.

{{PMID|20427696|OA=1
}} Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.

{{PMID|20562440|OA=1
}} FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

{{PMID|20565855|OA=1
}} Genetic variation in lipid desaturases and its impact on the development of human disease.

{{PMID|20691134}} Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.

{{PMID|21593353}} FADS1 genetic variability interacts with dietary alpha-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.

{{PMID|21793953}} FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.

{{PMID Auto
|PMID=23016130
|Title=Association between Polymorphisms in the Fatty Acid Desaturase Gene Cluster and the Plasma Triacylglycerol Response to an n-3 PUFA Supplementation
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs174546
|overall_frequency_n=917
|overall_frequency_d=3234
|overall_frequency=0.28355
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24890013
|Title=Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after controlled intake of n-3 polyunsaturated fatty acids
}}

{{PMID Auto
|PMID=25008580
|Title=Genetic Variation in FADS Has Little Effect on the Association between Dietary PUFA Intake and Cardiovascular Disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}