{{Rsnum
|rsid=174547
|Gene=FADS1
|Chromosome=11
|position=61803311
|Orientation=plus
|GMAF=0.3297
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FADS1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 12.5 | 43.8 | 43.8
| HCB | 15.3 | 44.5 | 40.1
| JPT | 10.7 | 42.9 | 46.4
| YRI | 0.0 | 2.1 | 97.9
| ASW | 0.0 | 15.8 | 84.2
| CHB | 15.3 | 44.5 | 40.1
| CHD | 29.6 | 41.7 | 28.7
| GIH | 0.0 | 18.0 | 82.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 43.9 | 43.9 | 12.3
| MKK | 0.7 | 13.2 | 86.1
| TSI | 8.1 | 34.3 | 57.6
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=C
|Pval=2E-12
|OR=0.09
|ORtxt=[0.05-0.13] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs174547
|Name_s=
|Gene_s=FADS1
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 11q12.2; Reported Gene(s): FADS1, FADS2, FADS3; Risk Allele: rs174547-C); (p-value= 0.000000000002).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740234
}}
{{PMID Auto GWAS
|PMID=20037589
|Trait=Serum metabolites
|Title=A genome-wide perspective of genetic variation in human metabolism
|RiskAllele=T
|Pval=0
|OR=36.30
|ORtxt=[NR] % variance explained
|OA=1
}}

{{PMID Auto GWAS
|PMID=20639392
|Trait=Resting heart rate
|Title=Genome-wide association analysis identifies multiple loci related with resting heart rate
|RiskAllele=C
|Pval=2E-9
|OR=6.20
|ORtxt=[4.22-8.18] ms decrease
|OA=1
}}

{{PharmGKB
|RSID=rs174547
|Name_s=
|Gene_s=FADS1
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 11q12.2; Reported Gene(s): FADS1, FADS2, FADS3; Risk Allele: rs174547-C); (p-value= 0.00000000000002).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740269
}}

{{PMID Auto GWAS
|PMID=21829377
|Trait=None
|Title=Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium.
|RiskAllele=T
|Pval=3E-64
|OR=0.0200
|ORtxt=[NR] % decrease
|OA=1
}}

{{PMID Auto GWAS
|PMID=21886157
|Trait=None
|Title=Human metabolic individuality in biomedical and pharmaceutical research.
|RiskAllele=C
|Pval=9E-116
|OR=0.1780
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22451038
|Title=Intake levels of dietary long-chain polyunsaturated fatty acids modify the association between genetic variation in FADS and LDL cholesterol
|OA=1
}}

{{PMID Auto GWAS
|PMID=22286219
|Trait=None
|Title=Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|RiskAllele=
|Pval=0
|OR=0.5700
|ORtxt=None
|OA=1
}}

{{PMID|19750004|OA=1
}} A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.

{{PMID|19798445|OA=1
}} Genetic determinants of circulating sphingolipid concentrations in European populations.

{{PMID|19951432|OA=1
}} Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

{{PMID|20364269}} A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.

{{PMID|20385826|OA=1
}} Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

{{PMID|20565855|OA=1
}} Genetic variation in lipid desaturases and its impact on the development of human disease.

{{PMID|20972250}} Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.

{{PMID|21347282|OA=1
}} Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

{{PMID|21414826}} Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs174547
|overall_frequency_n=1998
|overall_frequency_d=7820
|overall_frequency=0.255499
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22960237
  |Trait=Comprehensive strength and appendicular lean mass
  |Title=Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.
  |RiskAllele=C
  |Pval=2E-7
  |OR=NR
  |ORtxt=NR
  }}

{{PMID Auto
|PMID=23808484
|Title=Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}