{{Rsnum
|rsid=174548
|Gene=FADS1
|Chromosome=11
|position=61803876
|Orientation=plus
|GMAF=0.3439
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=FADS1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 47.8 | 44.2 | 8.0
| HCB | 41.6 | 43.8 | 14.6
| JPT | 46.9 | 42.5 | 10.6
| YRI | 74.8 | 22.4 | 2.7
| ASW | 63.2 | 36.8 | 0.0
| CHB | 41.6 | 43.8 | 14.6
| CHD | 30.3 | 41.3 | 28.4
| GIH | 82.2 | 17.8 | 0.0
| LWK | 66.4 | 30.9 | 2.7
| MEX | 13.8 | 39.7 | 46.6
| MKK | 46.2 | 44.9 | 9.0
| TSI | 59.8 | 35.3 | 4.9
| HapMapRevision=28
}}
FADS1 codes for an enzyme involved in fatty acid unsaturation and the [[FADS1]] gene SNP [[rs174548]] seems to explain as much as ten percent of the variance in the metabolism of some glycerophospholipids. [http://www.genomeweb.com/issues/news/150990-1.html news]

A study of metabolite concentrations in the blood of 284 adult males from Southern Germany determined that several SNPs were associated either directly with a metabolite range or with a ratio of metabolites. The rarer [[rs174548]](G) allele was associated with decreased phosphatidylcholine values. {{doi|10.1371/journal.pgen.1000282}}

[[Image:rs174548_295x287.jpg|295px|thumb|left|]]

{{PMID Auto GWAS
|PMID=19043545
|Trait=Serum metabolites
|Title=Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
|RiskAllele=
|Pval=5E-8
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs174548
|Name_s=
|Gene_s=FADS1
|Feature=
|Evidence=PubMed ID:19043545; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum. (Initial Sample Size: 284 males; Replication Sample Size: NR); (Region: 11q12.2; Reported Gene(s): FADS1; Risk Allele: rs174548-?); (p-value= 0.00000005).This variant is associated with Serum metabolites.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740318
}}

{{PMID Auto GWAS
|PMID=20864672
|Trait=None
|Title=Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
|RiskAllele=G
|Pval=1E-12
|OR=0.01
|ORtxt=[0.007-0.015] unit decrease
|OA=1
}}

{{PMID Auto
|PMID=22960237
|Title=Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs174548
|overall_frequency_n=41
|overall_frequency_d=128
|overall_frequency=0.320312
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23303382
  |Trait=Hematology traits
  |Title=Genome-wide association study of serum albumin:globulin ratio in Korean populations.
  |RiskAllele=G
  |Pval=4E-8
  |OR=.02
  |ORtxt=[0.011-0.023] unit increase
  }}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}