{{Rsnum
|rsid=174570
|Gene=FADS2
|Chromosome=11
|position=61829740
|Orientation=plus
|GMAF=0.2351
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FADS2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 76.8 | 19.6 | 3.6
| HCB | 40.1 | 44.5 | 15.3
| JPT | 45.5 | 43.8 | 10.7
| YRI | 98.6 | 1.4 | 0.0
| ASW | 93.0 | 7.0 | 0.0
| CHB | 40.1 | 44.5 | 15.3
| CHD | 28.4 | 43.1 | 28.4
| GIH | 95.0 | 5.0 | 0.0
| LWK | 99.1 | 0.9 | 0.0
| MEX | 27.6 | 39.7 | 32.8
| MKK | 91.7 | 8.3 | 0.0
| TSI | 81.4 | 17.6 | 1.0
| HapMapRevision=28
}}per the [http://blog.23andme.com/2008/12/08/new-papers-from-nature-genetics-yield-a-bounty-of-cholesterol-snps/ 23andMe blog], the minor allele of this SNP (T) was associated with decreased [[cholesterol]] and increased [[triglycerides]]
 
{| border="1"
|-
!SNP
!Rarer allele
!LDL
!HDL
!TG
|-
| [[rs6544713]] || T || + || ||
|-
| [[rs2650000]] || A || + || ||
|-
| [[rs471364]] || C || || - ||
|-
| [[rs1800961]] || T || || - ||
|-
| [[rs7679]] || C || || - || +
|-
| [[rs2967605]] || T || || - ||
|-
| [[rs2409722]] || T || || || -
|-
| [[rs10903129]] || A || - || - || -
|-
| [[rs6756629]] || A || - || + || -
|-
| [[rs12670798]] || C || + || + || +
|-
| [[rs7395662]] || A || - || + || +
|-
| [[rs174570]] || T || - || - || +
|-
| [[rs2271293]] || A || - || + || -
|-
| [[rs2624265]] || C || || || +
|-
| [[rs2167079]] || T || || + ||
|-
| [[rs9891572]] || T || || + ||
|-
| [[rs4844614]] || T || + || ||
|-
| [[rs5031002]] || G || + || ||
|-
|}

{{PMID Auto GWAS
|PMID=19060911
|Trait=Cholesterol, total
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=2E-10
|OR=0.09
|ORtxt=[NR] SD increase
|OA=1
}}

{{PharmGKB
|RSID=rs174570
|Name_s=
|Gene_s=FADS2
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 21,412 individuals; Replication Sample Size: NR); (Region: 11q12.2; Reported Gene(s): FADS2, FADS3; Risk Allele: rs174570-G); (p-value= 0.000004).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740210
}}

{{PMID Auto
|PMID=20484448
|Title=Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study
}}

{{PharmGKB
|RSID=rs174570
|Name_s=
|Gene_s=FADS2
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 22,562 individuals; Replication Sample Size: NR); (Region: 11q12.2; Reported Gene(s): FADS2, FADS3; Risk Allele: rs174570-G); (p-value= 0.0000000002).This variant is associated with Cholesterol, total.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740199
}}

{{PharmGKB
|RSID=rs174570
|Name_s=
|Gene_s=FADS2
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 17,797 individuals; Replication Sample Size: NR); (Region: 11q12.2; Reported Gene(s): FADS2, FADS3; Risk Allele: rs174570-G); (p-value= 0.0000000000004).This variant is associated with LDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740223
}}

{{PMID Auto
|PMID=19798445
|Title=Genetic determinants of circulating sphingolipid concentrations in European populations.
|OA=1
}}

{{PMID Auto
|PMID=19944404
|Title=Genomic dissection of population substructure of Han Chinese and its implication in association studies.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20502693
|Title=Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=20565855
|Title=Genetic variation in lipid desaturases and its impact on the development of human disease.
|OA=1
}}

{{PMID Auto
|PMID=21383846
|Title=Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs174570
|overall_frequency_n=19
|overall_frequency_d=128
|overall_frequency=0.148438
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}