{{Rsnum
|rsid=1746048
|Chromosome=10
|position=44775824
|Orientation=plus
|GMAF=0.2833
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 70.8 | 29.2 | 0.0
| HCB | 43.8 | 40.9 | 15.3
| JPT | 48.7 | 40.7 | 10.6
| YRI | 16.3 | 55.8 | 27.9
| ASW | 29.8 | 45.6 | 24.6
| CHB | 43.8 | 40.9 | 15.3
| CHD | 46.8 | 41.3 | 11.9
| GIH | 43.6 | 50.5 | 5.9
| LWK | 24.8 | 40.4 | 34.9
| MEX | 75.4 | 22.8 | 1.8
| MKK | 25.0 | 53.2 | 21.8
| TSI | 71.6 | 25.5 | 2.9
| HapMapRevision=28
}}

[http://blog.23andme.com/2009/02/09/snpwatch-five-new-studies-identify-genetic-variations-associated-with-coronary-artery-disease-and-heart-attack/ 23andMe blog] [[coronary artery disease]] and [[heart attack]]

SNP 	Risk Version 	Effect 
*[[rs646776]] 	T 	1.19 	
*[[rs17465637]] 	C 	1.14 
*[[rs1746048]] 	C 	1.17 	
*[[rs6725887]] 	C 	1.17 	
*[[rs11206510]] 	T 	1.15 	
*[[rs3184504]] 	T 	1.13 
*[[rs2306374]] 	C 	1.15 
*[[rs3782886]] 	C 	1.44

{{PMID Auto GWAS
|PMID=19198609
|Trait=Myocardial infarction (early onset)
|Title=Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
|RiskAllele=C
|Pval=7E-9
|OR=1.17
|ORtxt=[1.11-1.24]
|OA=1
}}

{{PharmGKB
|RSID=rs1746048
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19198609; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (Initial Sample Size: 2,967 cases, 3,075 controls; Replication Sample Size: 9,746 cases, 9,746 controls); (Region: 10q11.21; Reported Gene(s): CXCL12; Risk Allele: rs1746048-C); (p-value= 0.000000007).This variant is associated with Myocardial infarction (early onset).
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739968
}}

{{PharmGKB
|RSID=rs1746048
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19198609
|Annotation=In a genome-wide association study this variant (rs1746048) near CXCL12 was associated with with early-onset myocardial infarction in 2,967 cases and 3,075 controls.
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA162565801
}}

{{PMID Auto GWAS
|PMID=21378990
|Trait=None
|Title=Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
|RiskAllele=C
|Pval=3E-10
|OR=1.0900
|ORtxt=[1.07-1.13]
|OA=1
}}

{{PMID Auto
|PMID=21415067
|Title=The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels
|OA=1
}}

{{PMID Auto
|PMID=19956433
|Title=Genetics of coronary artery disease: focus on genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20835900
|Title=Genetics of diabetes complications.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1746048
|overall_frequency_n=47
|overall_frequency_d=128
|overall_frequency=0.367188
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=43
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Coronary Heart Disease]]

{{PMID Auto
|PMID=23531450
|Title=Relationship between Chemokine (C-X-C motif) ligand 12 gene variant (rs1746048) and coronary heart disease: Case-control study and meta-analysis
}}

{{PMID Auto
|PMID=23666823
|Title=Genetic variants on chromosome 10q11.21 are associated with ischemic stroke in the northern Chinese Han population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}