{{Rsnum
|rsid=17465637
|Gene=MIA3
|Chromosome=1
|position=222650187
|Orientation=plus
|GMAF=0.4518
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=MIA3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 3.6 | 46.4 | 50.0
| HCB | 16.8 | 40.1 | 43.1
| JPT | 24.8 | 40.7 | 34.5
| YRI | 72.8 | 24.5 | 2.7
| ASW | 54.4 | 35.1 | 10.5
| CHB | 16.8 | 40.1 | 43.1
| CHD | 11.9 | 45.0 | 43.1
| GIH | 9.9 | 49.5 | 40.6
| LWK | 72.7 | 25.5 | 1.8
| MEX | 13.8 | 51.7 | 34.5
| MKK | 57.7 | 36.5 | 5.8
| TSI | 6.9 | 31.4 | 61.8
| HapMapRevision=28
}}[[rs17465637]] is a SNP found to be associated with [[heart disease]] by the German MI (Myocardial infarction) Family Study group {{PMID|17634449|OA=1
}}

{{PMID|21264445}} This 2011 study concluded that the only [[MIA3]] gene SNP to be associated with increased risk for [[myocardial infarction]] is [[rs17465637]], with an odds ratio of 1.17 (CI: 1.04-1.32) and 1.37 (CI: 1.08-1.74) for carriers of one or two (C) alleles, respectively.

[http://blog.23andme.com/2009/02/09/snpwatch-five-new-studies-identify-genetic-variations-associated-with-coronary-artery-disease-and-heart-attack/ 23andMe blog] [[coronary artery disease]] and [[heart attack]]

SNP 	Risk Version 	Effect 
*[[rs646776]] 	T 	1.19 	
*[[rs17465637]] 	C 	1.14 
*[[rs1746048]] 	C 	1.17 	
*[[rs6725887]] 	C 	1.17 	
*[[rs11206510]] 	T 	1.15 	
*[[rs3184504]] 	T 	1.13 
*[[rs2306374]] 	C 	1.15 
*[[rs3782886]] 	C 	1.44

{{PMID Auto GWAS
|PMID=19198609
|Trait=Myocardial infarction (early onset)
|Title=Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
|RiskAllele=C
|Pval=1E-9
|OR=1.14
|ORtxt=[1.10-1.19]
|OA=1
}}

{{PharmGKB
|RSID=rs17465637
|Name_s=
|Gene_s=MIA3
|Feature=
|Evidence=PubMed ID:19198609; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (Initial Sample Size: 2,967 cases, 3,075 controls; Replication Sample Size: 9,746 cases, 9,746 controls); (Region: 1q41; Reported Gene(s): MIA3; Risk Allele: rs17465637-C); (p-value= 0.000000001).This variant is associated with Myocardial infarction (early onset).
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739966
}}

{{PharmGKB
|RSID=rs17465637
|Name_s=
|Gene_s=MIA3
|Feature=
|Evidence=PubMed ID:19198609
|Annotation=In a genome-wide association study this variant (rs17465637) in MIA3 was associated with with early-onset myocardial infarction in 2,967 cases and 3,075 controls.
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA162565803
}}

{{PMID Auto
|PMID=21463265
|Title=Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population
|OA=1
}}

{{PMID Auto GWAS
|PMID=21378990
|Trait=None
|Title=Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
|RiskAllele=C
|Pval=1E-8
|OR=1.1400
|ORtxt=[1.09-1.20]
|OA=1
}}

{{PMID Auto
|PMID=22856164
|Title=[Evaluation of association between 9 genetic polymorphism and myocardial infarction in the Siberian population]
}}

{{PMID Auto
|PMID=18654002
|Title=Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese population.
}}

{{PMID Auto
|PMID=18979498
|Title=The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.
|OA=1
}}

{{PMID Auto
|PMID=19750184
|Title=Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
|OA=1
}}

{{PMID Auto
|PMID=19956433
|Title=Genetics of coronary artery disease: focus on genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20017983
|Title=Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
|OA=1
}}

{{PMID Auto
|PMID=20098575
|Title=Genetics and cardiovascular disease: Design and development of a DNA biobank.
|OA=1
}}

{{PMID Auto
|PMID=20835900
|Title=Genetics of diabetes complications.
|OA=1
}}

{{PMID Auto
|PMID=21804106
|Title=Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.
|OA=1
}}

{{PMID Auto
|PMID=21984477
|Title=Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease.
}}

{{PMID Auto
|PMID=22577832
|Title=Association Study of MIA3 rs17465637 Polymorphism with Cardiovascular Disease in Rheumatoid Arthritis Patients.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17465637
|overall_frequency_n=71
|overall_frequency_d=128
|overall_frequency=0.554688
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=56
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24125424
|Title=Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}