{{Rsnum
|rsid=17482078
|Gene=ERAP1
|Chromosome=5
|position=96783162
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1304
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ERAP1,LOC102724748
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 58.0 | 34.8 | 7.1
| HCB | 85.7 | 14.3 | 0.0
| JPT | 83.9 | 16.1 | 0.0
| YRI | 88.4 | 9.5 | 2.0
| ASW | 83.9 | 14.3 | 1.8
| CHB | 85.7 | 14.3 | 0.0
| CHD | 89.8 | 10.2 | 0.0
| GIH | 89.0 | 11.0 | 0.0
| LWK | 89.1 | 10.0 | 0.9
| MEX | 82.1 | 17.9 | 0.0
| MKK | 92.3 | 7.1 | 0.6
| TSI | 64.7 | 33.3 | 2.0
| HapMapRevision=28
}}[[rs17482078]] is one of several SNPs in the [[ERAP1]] gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with [[ankylosing spondylitis]]. The odds ratio is 0.70 (p=1.2x10e-8).[PMID 17952073, PMID 18037607]

{{ neighbor
| rsid = 27044
| distance = 14
}}

{{PMID Auto
|PMID=20032103
|Title=Association of ARTS1 Gene Polymorphisms with Ankylosing Spondylitis in the Hungarian Population: The rs27044 Variant Is Associated with HLA-B*2705 Subtype in Hungarian Patients with Ankylosing Spondylitis
}}

{{PMID Auto
|PMID=19414429
|Title=ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans
}}

{{PMID Auto
|PMID=21229357
|Title=The association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls
}}

{{PMID Auto
|PMID=19692350
|Title=Investigating the genetic association between ERAP1 and ankylosing spondylitis.
|OA=1
}}

{{PMID Auto
|PMID=21865284
|Title=ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population.
}}

{{PMID Auto
|PMID=21877190
|Title=Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
}}

{{PMID Auto
|PMID=22896742
|Title=Investigating the genetic association between ERAP1 and spondyloarthritis
}}

{{GET Evidence
|gene=ERAP1
|aa_change=Arg725Gln
|aa_change_short=R725Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17482078
|overall_frequency_n=1793
|overall_frequency_d=10758
|overall_frequency=0.166667
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=11
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.974
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23291587
  |Trait=Behcet's disease
  |Title=Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
  |RiskAllele=T
  |Pval=4E-8
  |OR=3.08
  |ORtxt=[2.04-4.65]
  |OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}