{{Rsnum
|rsid=17487223
|Gene=CHRNB4
|Chromosome=15
|position=78631645
|Orientation=plus
|GMAF=0.2094
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CHRNB4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 35.4 | 44.6 | 20.0
| HCB | 93.3 | 6.7 | 0.0
| JPT | 95.5 | 4.5 | 0.0
| YRI | 87.3 | 12.7 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 93.3 | 6.7 | 0.0
| CHD | 91.7 | 8.3 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 48.0 | 42.6 | 9.5
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{Report GE
|PubMed=18385738
|Source=journal
|AffyProbeset=SNP_A-8440085
|AffyOrientation=reverse
|AlleleA=A
|AlleleB=G
|onGW5=
|rsid=17487223
|ancestral=
|RiskPopulation=Caucasian(Europe)
|RiskAllele=T
|CaseFreq=0.42
|ControlFreq=0.36
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.28
|Disease=Lung cancer
|DiseaseSymbol=LC
}}

rs17487223 increases susceptibility to Lung cancer 1.28 times for carriers of the T allele {{PMID|18385738}}

[http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000125 plos] Risk Factors for Age-Dependent Nicotine Addiction

{{PMID Auto
|PMID=18519524
|Title=Variants in nicotinic receptors and risk for nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18618000
|Title=A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.
|OA=1
}}

{{PMID Auto
|PMID=18759969
|Title=In search of causal variants: refining disease association signals using cross-population contrasts.
|OA=1
}}

{{PMID Auto
|PMID=19029397
|Title=Nicotinic receptor gene variants influence susceptibility to heavy smoking.
|OA=1
}}

{{PMID Auto
|PMID=19259974
|Title=Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
|OA=1
}}

{{PMID Auto
|PMID=19330903
|Title=Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.
|OA=1
}}

{{PMID Auto
|PMID=19443489
|Title=Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
|OA=1
}}

{{PMID Auto
|PMID=19706762
|Title=The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}