{{Rsnum
|rsid=17561
|Gene=IL1A
|Chromosome=2
|position=112779646
|Orientation=minus
|GMAF=0.2029
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=IL1A
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 55.8 | 37.2 | 7.1
| HCB | 85.5 | 14.5 | 0.0
| JPT | 77.5 | 20.7 | 1.8
| YRI | 66.9 | 31.7 | 1.4
| ASW | 71.9 | 28.1 | 0.0
| CHB | 85.5 | 14.5 | 0.0
| CHD | 83.0 | 17.0 | 0.0
| GIH | 46.0 | 44.0 | 10.0
| LWK | 64.5 | 31.8 | 3.7
| MEX | 57.9 | 36.8 | 5.3
| MKK | 59.5 | 33.3 | 7.2
| TSI | 54.5 | 36.6 | 8.9
| HapMapRevision=28
}}{{PMID Auto
|PMID=20157068
|Title=Association of IL1A, IL1B, and TNF Gene Polymorphisms With Chronic Rhinosinusitis With and Without Nasal Polyposis: A Replication Study
}}

{{PMID Auto
|PMID=22216303
|Title=Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice
|OA=1
}}

{{PMID Auto
|PMID=16642433
|Title=Polymorphism in maternal LRP8 gene is associated with fetal growth.
|OA=1
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=16842617
|Title=Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.
|OA=1
}}

{{PMID Auto
|PMID=16918024
|Title=Association between the interleukin-1 family gene cluster and psoriatic arthritis.
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17665434
|Title=Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=17932347
|Title=Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic Technologists.
}}

{{PMID Auto
|PMID=18063673
|Title=Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis.
}}

{{PMID Auto
|PMID=18454203
|Title=Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression.
|OA=1
}}

{{PMID Auto
|PMID=18576312
|Title=A broad analysis of IL1 polymorphism and rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=18609743
|Title=Genetics of psoriasis and psoriatic arthritis: update and future direction.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18727828
|Title=Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study.
|OA=1
}}

{{PMID Auto
|PMID=18838388
|Title=Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis.
}}

{{PMID Auto
|PMID=18978339
|Title=Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.
|OA=1
}}

{{PMID Auto
|PMID=19035492
|Title=Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis.
|OA=1
}}

{{PMID Auto
|PMID=19043479
|Title=Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19468064
|Title=Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
|OA=1
}}

{{PMID Auto
|PMID=19934104
|Title=Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.
|OA=1
}}

{{PMID Auto
|PMID=20113413
|Title=Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation.
}}

{{PMID Auto
|PMID=20192980
|Title=The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.
}}

{{PMID Auto
|PMID=20459687
|Title=Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
|OA=1
}}

{{PMID Auto
|PMID=20725607
|Title=CCL3 genotype and current depression increase risk of HIV-associated dementia.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=21279638
|Title=Coding single-nucleotide polymorphisms of interleukin-1 gene cluster are not associated with Kawasaki disease in the Korean population.
}}

{{PMID Auto
|PMID=21621860
|Title=Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-alpha polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.
}}

{{PMID Auto
|PMID=22282663
|Title=Ovarian cancer risk associated with inherited inflammation-related variants.
|OA=1
}}

{{GET Evidence
|gene=IL1A
|aa_change=Ala114Ser
|aa_change_short=A114S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17561
|overall_frequency_n=2787
|overall_frequency_d=10758
|overall_frequency=0.259063
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.061
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22723975
|Title=Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study
|OA=1
}}

{{PMID Auto
|PMID=23927441
|Title=Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus
|OA=1
}}

{{PMID Auto
|PMID=24272484
|Title=Risk of Ovarian Cancer and the NF-κB Pathway: Genetic association with IL1A and TNFSF10
}}

{{PMID Auto
|PMID=21962386
|Title=The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.
}}

{{PMID Auto
|PMID=23459936
|Title=Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=24862933
|Title=Association of an insertion/deletion polymorphism in IL1A 3'-UTR with risk for cervical carcinoma in Chinese Han Women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}