{{Rsnum
|rsid=17563
|Gene=BMP4
|Chromosome=14
|position=53950804
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.3714
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=BMP4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 37.2 | 46.9 | 15.9
| HCB | 8.0 | 44.5 | 47.4
| JPT | 6.2 | 37.2 | 56.6
| YRI | 2.0 | 25.9 | 72.1
| ASW | 5.3 | 33.3 | 61.4
| CHB | 8.0 | 44.5 | 47.4
| CHD | 8.3 | 36.7 | 55.0
| GIH | 6.9 | 50.5 | 42.6
| LWK | 5.5 | 35.5 | 59.1
| MEX | 10.3 | 44.8 | 44.8
| MKK | 5.8 | 48.1 | 46.2
| TSI | 25.5 | 46.1 | 28.4
| HapMapRevision=28
}}

{{PMID|18021008|OA=1
}} [[rs17563]](G) allele, coding for the amino acid alanine, confers susceptibility to otosclerosis (combined populations: p = 0.002; OR = 1.209; 95% CI: 1.070-1.370)

{{PMID Auto
|PMID=19557432
|Title=A predicted functional single-nucleotide polymorphism of bone morphogenetic protein-4 gene affects mRNA expression and shows a significant association with cutaneous melanoma in Southern Italian population
}}

{{PMID Auto
|PMID=21034624
|Title=T allele at site 6007 of bone morphogenetic protein-4 gene increases genetic susceptibility to ossification of the posterior longitudinal ligament in male Chinese Han population
}}

{{PMID Auto
|PMID=22191848
|Title=TGFB3 and BMP4 polymorphism are associated with isolated tooth agenesis
}}

{{PMID Auto
|PMID=18551993
|Title=SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.
}}

{{PMID Auto
|PMID=19011631
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20057906
|Title=Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma.
|OA=1
}}

{{PMID Auto
|PMID=22052794
|Title=A new haplotype in BMP4 implicated in ossification of the posterior longitudinal ligament (OPLL) in a Chinese population.
}}

{{GET Evidence
|gene=BMP4
|aa_change=Val152Ala
|aa_change_short=V152A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17563
|overall_frequency_n=4761
|overall_frequency_d=10758
|overall_frequency=0.442554
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=37
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.958
|nblosum100=2
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23704328
  |Trait=Primary tooth development (time to first tooth eruption)
  |Title=Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
  |RiskAllele=G
  |Pval=9E-17
  |OR=.24
  |ORtxt=[0.18-0.3] unit decrease
  |OA=1
}}

{{PMID Auto
|PMID=24559233
|Title=Genetic analysis of BMP4 gene in Chinese Han female population with premature ovarian insufficiency
}}

{{PMID Auto
|PMID=22886282
|Title=Association of BMPR1A polymorphism, but not BMP4, with kidney size in full-term newborns.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}