{{Rsnum
|rsid=17576
|Gene=MMP9
|Chromosome=20
|position=46011586
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.4495
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MMP9
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 38.1 | 51.3 | 10.6
| HCB | 7.3 | 38.0 | 54.7
| JPT | 14.2 | 47.8 | 38.1
| YRI | 36.7 | 48.3 | 15.0
| ASW | 47.4 | 36.8 | 15.8
| CHB | 7.3 | 38.0 | 54.7
| CHD | 5.5 | 45.0 | 49.5
| GIH | 25.7 | 36.6 | 37.6
| LWK | 45.9 | 43.1 | 11.0
| MEX | 46.6 | 36.2 | 17.2
| MKK | 30.1 | 46.8 | 23.1
| TSI | 44.1 | 38.2 | 17.6
| HapMapRevision=28
}}[[rs17576]], also known as Gln279Arg or Q279R, is a SNP in exon 6 of the matrix metalloproteinase-9 [[MMP9]] gene. The [[rs17576]](G) allele encodes the Arg (R).

In a study of 385 male veterans with greater than 20 pack-years of cigarette smoking, [[rs17576]](G) allele carriers were at higher risk for [[chronic obstructive pulmonary disease]] (COPD). The [[rs17576]](G;G) homozygous genotype was at 3-fold increased risk for COPD.{{PMID|18046864|OA=1
}}

A study of 744 Chinese patients with [[lung cancer]] found that the [[rs17576]](G;G) genotype was associated with higher risk of lung cancer with metastasis (adjusted OR, 1.79, CI: 1.03-3.08) compared to the (A;A) genotype.{{PMID|16061858}}

[[rs17576]] is also one of two SNPs in the [[MMP9]] gene associated with increased risk for myocardial infarction, but not coronary artery disease. The relatively weak odds ratios for carriers of one [[rs17576]](A) allele was 1.15 (p=0.26), and for (A;A) homozygotes, 1.09 (p=0.33). However, this study of 5,000+ Caucasian patients with [[heart disease]] also indicated that a composite genotype (i.e. unphased haplotype) of the two [[MMP9]] SNPs ([[rs3918242]] and [[rs17576]], respectively) yielded a significant odds ratio of 1.25 (CI: 1.07 - 1.48, p=0.007) for the (C;T)/(A;G) combination compared to (C;C)/(G;G) combination genotypes.{{PMID|17893005|OA=1
}}

{{PMID|18455130|OA=1
}} (IVS10-8C  T; [[rs9406328]]) and (Q279R; [[rs17576]]) showed significant association with lumbar-disc herniation (odds ratio 3.03, 95% confidence interval 1.58-5.77)

{{omim
|desc=INTERVERTEBRAL DISC DISEASE; IDD
|id=603932
|rsnum=17576
}}

{{omim
|desc=MATRIX METALLOPROTEINASE 9; MMP9
|id=120361
|rsnum=17576
}}

{{omim
|desc=THROMBOSPONDIN II; THBS2
|id=188061
|rsnum=17576
}}
{{PMID Auto
|PMID=19633731
|Title=Association of the single nucleotide polymorphisms in the extracellular matrix metalloprotease-9 gene with PACG in southern China
|OA=1
}}

{{PharmGKB
|RSID=rs17576
|Name_s=
|Gene_s=MMP9
|Feature=
|Evidence=PubMed ID:18455130
|Annotation=In two independent Japanese populations, this SNP was associated with susceptibility to Lumbar Disc herniation.
|Drugs=
|Drug Classes=
|Diseases=Lumbar Disc Herniation
|Curation Level=Curated
|PharmGKB Accession ID=PA161615644
}}

{{PMID Auto
|PMID=20144500
|Title=Matrix metalloproteinase-9 polymorphism and risk of pelvic organ prolapse in Taiwanese women
}}

{{PMID Auto
|PMID=19906411
|Title=Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer
|OA=1
}}

{{PMID Auto
|PMID=20808730
|Title=Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas
|OA=1
}}

{{PMID Auto
|PMID=22107133
|Title=Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia
}}

{{PMID Auto
|PMID=22113040
|Title=[Study on association between single nucleotide polymorphisms of MMP7, MMP8, MMP9 genes and development of gastric cancer and lymph node metastasis]
}}

{{PMID Auto
|PMID=22664146
|Title=Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients
}}

{{PMID|15748780}} Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease.

{{PMID|17110919}} The association of single nucleotide polymorphisms in the MMP-9 genes with susceptibility to acute primary angle closure glaucoma in Taiwanese patients.

{{PMID|17346338|OA=1
}} Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma.

{{PMID|18191955|OA=1
}} Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.

{{PMID|18303200|OA=1
}} Matrix metalloproteinase-3 genotypes influence recovery from hepatitis B virus infection.

{{PMID|18512818}} Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis.

{{PMID|18552608}} Lack of association between the rs2664538 polymorphism in the MMP-9 gene and primary angle closure glaucoma in Singaporean subjects.

{{PMID|18636124|OA=1
}} Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.

{{PMID|18781223|OA=1
}} The association of membrane frizzled-related protein (MFRP) gene with acute angle-closure glaucoma--a pilot study.

{{PMID|19064570|OA=1
}} Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk.

{{PMID|19357773|OA=1
}} Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.

{{PMID|19898635|OA=1
}} Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma.

{{PMID|20078883|OA=1
}} Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.

{{PMID|20181264|OA=1
}} MMP-9 gene variants increase the risk for non-atopic asthma in children.

{{PMID|20529372|OA=1
}} Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis.

{{PMID|21048031|OA=1
}} Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

{{PMID|21150032|OA=1
}} Complex genetic mechanisms in glaucoma: an overview.

{{PMID|21844877}} Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children.

{{GET Evidence
|gene=MMP9
|aa_change=Gln279Arg
|aa_change_short=Q279R
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17576
|overall_frequency_n=3726
|overall_frequency_d=10758
|overall_frequency=0.346347
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23441116
|Title=Polymorphisms in matrix metalloproteinases MMP1 and MMP9 are associated with primary open-angle and angle closure glaucoma in a Pakistani population
|OA=1
}}

{{PMID Auto
|PMID=23819814
|Title=Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in Chinese Han Population: A Case-Control Study
}}

{{PMID Auto
|PMID=22710194
|Title=MMP13 polymorphism decreases risk for dental caries.
}}

{{PMID Auto
|PMID=23010359
|Title=Functional matrix metalloproteinase (MMP)-9 genetic variants modify the effects of hemodialysis on circulating MMP-9 levels.
}}

{{PMID Auto
|PMID=25162123
|Title=MMP9 Gene Polymorphism is not Associated with Polypoidal Choroidal Vasculopathy and Neovascular Age-related Macular Degeneration in a Chinese Han Population
}}

{{PMID Auto
|PMID=23955812
|Title=Functional polymorphisms of matrix metalloproteinase-9 and survival in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}