{{Rsnum
|rsid=17611
|Gene=C5
|Chromosome=9
|position=121006922
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.4073
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=C5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.7 | 44.2 | 38.1
| HCB | 35.8 | 46.0 | 18.2
| JPT | 33.6 | 50.4 | 15.9
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 29.8 | 70.2
| CHB | 35.8 | 46.0 | 18.2
| CHD | 33.0 | 49.5 | 17.4
| GIH | 41.6 | 47.5 | 10.9
| LWK | 0.0 | 3.6 | 96.4
| MEX | 20.7 | 51.7 | 27.6
| MKK | 2.6 | 24.4 | 73.1
| TSI | 22.5 | 55.9 | 21.6
| HapMapRevision=28
}}{{PMID|19028820}}  Although [[rs17611]] was the only SNP to remain significant after multivariate analysis (odds ratio 0.585, p = 0.0037) in a study of 459 patients, ROC curve analysis did not show any contribution of this SNP to overall [[stroke]] risk.

{{omim
|id=120900
|desc=COMPLEMENT COMPONENT 5; C5
|rsnum=17611
}}
{{PMID Auto
|PMID=19619703
|Title=Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study
|OA=1
}}

{{PMID Auto
|PMID=19909405
|Title=Single nucleotide polymorphisms of complement component 5 and periodontitis
}}

{{omim
|id=120900
|rsnum=17611
|variant=0005
}}

{{PMID Auto
|PMID=21871809
|Title=Complement Factor H Y402H polymorphism is associated with an increased risk of mortality after intracerebral hemorrhage
}}

{{PMID Auto
|PMID=22452399
|Title=Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis
}}

{{PMID Auto
|PMID=15371359
|Title=Testing for Hardy-Weinberg equilibrium in samples with related individuals.
|OA=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=17428459
|Title=Gc-globulin concentrations and C5 haplotype-tagging polymorphisms contribute to variations in serum activity of complement factor C5.
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=18644651
|Title=Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection.
}}

{{PMID Auto
|PMID=18648537
|Title=A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=20018035
|Title=A combinatorial approach for detecting gene-gene interaction using multiple traits of Genetic Analysis Workshop 16 rheumatoid arthritis data.
|OA=1
}}

{{PMID Auto
|PMID=21393613
|Title=Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea.
}}

{{GET Evidence
|gene=C5
|aa_change=Val802Ile
|aa_change_short=V802I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17611
|overall_frequency_n=3473
|overall_frequency_d=10758
|overall_frequency=0.32283
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.008
|nblosum100=-4
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23662819
|Title=Complement polymorphisms and cognitive dysfunction after carotid endarterectomy.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}