{{Rsnum
|rsid=17646946
|Gene=TCHHL1
|Chromosome=1
|position=152090291
|Orientation=plus
|GMAF=0.1368
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TCHHL1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 5.4 | 33.3 | 61.3
| HCB | 0.0 | 0.7 | 99.3
| JPT | 0.0 | 0.9 | 99.1
| YRI | 0.7 | 9.7 | 89.7
| ASW | 1.8 | 29.8 | 68.4
| CHB | 0.0 | 0.7 | 99.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 15.8 | 84.2
| LWK | 1.9 | 24.3 | 73.8
| MEX | 1.7 | 20.7 | 77.6
| MKK | 4.5 | 25.3 | 70.1
| TSI | 5.1 | 30.3 | 64.6
| HapMapRevision=28
}}

[[rs17646946]] is a SNP on chromosome 1 that is apparently part of the trichohyalin-like 1 [[TCHHL1]] gene. Trichohyalin is a protein found in hair follicle roots.

In an interesting example of people-powered research, this SNP and one other were reported to be associated with hair curliness. Source:
{{PMID|19896111|OA=1
}} hair curl [[rs17646946]] and [[rs7349332]]. source [http://scienceblogs.com/geneticfuture/2009/10/off_to_hawaii.php genetic] [http://scienceblogs.com/geneticfuture/2009/11/23andme_gets_scooped_on_hair_c.php#comment-2068102 future]

[[rs17646946]] and [[hair curl]] with each A conferring a reduction in curliness of about 0.29 points on a scale from 0 to 5.

See also: [[rs11803731]]

{{PMID Auto GWAS
|PMID=20585627
|Trait=Common traits (Other)
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits
|RiskAllele=A
|Pval=2E-42
|OR=0.29
|ORtxt=[NR] unit decrease
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}