{{Rsnum
|rsid=1780324
|Chromosome=1
|position=21495264
|Orientation=minus
|GMAF=0.4743
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 24.8 | 48.7 | 26.5
| HCB | 52.9 | 40.4 | 6.6
| JPT | 50.4 | 41.6 | 8.0
| YRI | 5.6 | 44.4 | 50.0
| ASW | 8.9 | 41.1 | 50.0
| CHB | 52.9 | 40.4 | 6.6
| CHD | 45.4 | 45.4 | 9.3
| GIH | 17.0 | 48.0 | 35.0
| LWK | 4.6 | 32.4 | 63.0
| MEX | 37.9 | 36.2 | 25.9
| MKK | 30.1 | 42.3 | 27.6
| TSI | 33.3 | 54.9 | 11.8
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18940312
|Trait=Plasma levels of liver enzymes
|Title=Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
|RiskAllele=T
|Pval=7E-15
|OR=0.03
|ORtxt=[0.023-0.039] U/L increase
|OA=1
}}

{{omim
|desc=ALKALINE PHOSPHATASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS 2
|id=612367
|rsnum=1780324
}}

{{PharmGKB
|RSID=rs1780324
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18940312; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (Initial Sample Size: 7,751 European white individuals; Replication Sample Size: 4,704 European white and Indian Asian individua); (Region: 1p36.12; Reported Gene(s): NBPF3, ALPL, RAP1GAP; Risk Allele: rs1780324-T); (p-value= 0.000000000000007).This variant is associated with Plasma levels of liver enzymes.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740810
}}

{{PMID Auto
|PMID=19303062
|Title=Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1780324
|overall_frequency_n=61
|overall_frequency_d=128
|overall_frequency=0.476562
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=52
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}