{{Rsnum
|rsid=1780329
|Gene=ALPL
|Chromosome=1
|position=21576457
|Orientation=minus
|GMAF=0.3159
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ALPL
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 67.3 | 28.3 | 4.4
| HCB | 27.4 | 54.8 | 17.8
| JPT | 15.9 | 52.2 | 31.9
| YRI | 37.4 | 45.6 | 17.0
| ASW | 50.9 | 43.9 | 5.3
| CHB | 27.4 | 54.8 | 17.8
| CHD | 29.4 | 40.4 | 30.3
| GIH | 61.4 | 29.7 | 8.9
| LWK | 48.2 | 40.0 | 11.8
| MEX | 44.8 | 43.1 | 12.1
| MKK | 60.9 | 32.7 | 6.4
| TSI | 75.5 | 23.5 | 1.0
| HapMapRevision=28
}}{{PMID|17195227}} A study of 201 Canadian [[ankylosing spondylitis]] families concluded the ALPL (TNAP) haplotype G-G-T for SNPs [[rs3767155]]-[[rs3738099]]-[[rs1780329]], respectively, is significantly associated with the disease but only in men.

{{PMID|18769922}} A study of 353 Chinese ankylosing spondylitis patients found no significant difference in allele, genotype or haplotype frequencies for this SNP in either case-control or family-based association studies, which indicated that the TNAP (also known as ALPL) gene is unlikely to play a major role in the susceptibility to ankylosing spondylitis in the Chinese Han population.

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}