{{Rsnum
|rsid=17817449
|Gene=FTO
|Chromosome=16
|position=53779455
|Orientation=plus
|GMAF=0.3242
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=FTO
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 17.7 | 56.6 | 25.7
| HCB | 2.2 | 22.8 | 75.0
| JPT | 2.7 | 31.9 | 65.5
| YRI | 15.8 | 47.3 | 37.0
| ASW | 21.1 | 43.9 | 35.1
| CHB | 2.2 | 22.8 | 75.0
| CHD | 2.8 | 25.7 | 71.6
| GIH | 6.9 | 36.6 | 56.4
| LWK | 16.5 | 46.8 | 36.7
| MEX | 1.8 | 35.1 | 63.2
| MKK | 24.5 | 51.6 | 23.9
| TSI | 23.5 | 43.1 | 33.3
| HapMapRevision=28
}}Within the [[FTO]] gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not [[rs17817449]], although this SNP is one of co-inherited SNPs in the [[FTO]] gene region. For more information, refer to the [[FTO]] gene or the most studied of [[FTO]] SNPs, [[rs9930506]]. {{PMID|17658951|OA=1
}}

{{PMID|18316358}} A study of 900+ Quebec individuals reported that [[rs17817449]] was associated with BMI (p=0.0014), weight (p=0.0059) and waist circumference (p=0.0021) under an additive model, and in addition, influenced fasting insulin (p=0.011) and HOMA-IR (p=0.038).

* Note: The three [[FTO]] SNPs, [[rs1421085]], [[rs17817449]], and [[rs9939609]], are in strong linkage disequilibrium (pairwise r<sup>2</sup>>0.97), and there are two primary haplotypes, C-G-A (42.0 %) and T-T-T (55.5 %).

{{PMID|18719664}} This SNP is also associated with adult [[obesity]] in Mexicans.

{{PMID|18551112}} [[rs1421085]](C) and [[rs17817449]](G) significantly associated with increased BMI. Our results suggest that FTO may be one of the worldwide obesity-risk genes.

{{ neighbor
| rsid = 8043757
| distance = 83
}}

{{PMID Auto
|PMID=19278366
|Title=A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies.
}}

{{PMID Auto
|PMID=19322589
|Title=Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
|OA=1
}}

{{omim
|desc=BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 14; BMIQ14
|id=612460
|rsnum=17817449
}}

{{PharmGKB
|RSID=rs17817449
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:18316358
|Annotation=The variant is significantly associated with several obesity-related phenotypes.
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Curated
|PharmGKB Accession ID=PA161660931
}}

{{PMID Auto
|PMID=20717169
|Title=FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males
|OA=1
}}
{{PMID Auto
|PMID=20945952
|Title=FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study
|OA=1
}}

{{PMID Auto GWAS
|PMID=21552555
|Trait=None
|Title=A genome-wide association study on obesity and obesity-related traits.
|RiskAllele=
|Pval=2E-12
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=20945953
|Title=Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms
}}

{{PMID Auto
|PMID=22030988
|Title=FTO Risk Haplotype Among Early Onset and Severe Obesity Cases in a Population of Western Spain
}}

{{PMID|17928949}} FTO polymorphisms in oceanic populations.

{{PMID|18218107|OA=1
}} FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs.

{{PMID|18256137|OA=1
}} Regulation of Fto/Ftm gene expression in mice and humans.

{{PMID|18487448|OA=1
}} Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.

{{PMID|18599522|OA=1
}} FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.

{{PMID|18647953|OA=1
}} Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.

{{PMID|18833210}} The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study.

{{PMID|19265514|OA=1
}} FTO gene variation and measures of body mass in an African population.

{{PMID|20080751|OA=1
}} Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.

{{PMID|20362563}} A FTO variant and risk of acute coronary syndrome.

{{PMID|20381893|OA=1
}} The genetics of obesity: FTO leads the way.

{{PMID|20404173|OA=1
}} A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.

{{PMID|20442772|OA=1
}} Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.

{{PMID|20502638|OA=1
}} Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.

{{PMID|21102551}} Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.

{{PMID|21283731|OA=1
}} FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

{{PMID|21317302|OA=1
}} FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.

{{PMID|21318054|OA=1
}} Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents.

{{PMID|21788373|OA=1
}} The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population.

{{PMID|21919686}} Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population.

{{PMID|22157232}} Lack of an association between three tagging SNPs within the FTO gene and smoking behavior.

{{PMID|22187296}} Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention.

{{PMID|22614171|OA=1
}} Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17817449
|overall_frequency_n=52
|overall_frequency_d=128
|overall_frequency=0.40625
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23136261
|Title=Fat mass and obesity gene and cognitive decline: The Atherosclerosis Risk in Communities Study
|OA=1
}}

{{PMID Auto
|PMID=24106974
|Title=Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility
}}

{{PMID Auto GWAS
  |PMID=23535733
  |Trait=Breast cancer
  |Title=Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
  |RiskAllele=T
  |Pval=6E-7
  |OR=1.09
  |ORtxt=[1.05-1.12]
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=23535729
  |Trait=Breast cancer
  |Title=Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
  |RiskAllele=T
  |Pval=6E-14
  |OR=1.08
  |ORtxt=[1.05-1.1]
  |OA=1
}}

{{PMID Auto
|PMID=22503908
|Title=Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study.
}}

{{PMID Auto
|PMID=23201545
|Title=FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention.
}}

{{PMID Auto
|PMID=23771786
|Title=Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}