{{Rsnum
|rsid=17822931
|Gene=ABCC11
|Chromosome=16
|position=48224287
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3085
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ABCC11
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 75.9 | 23.2 | 0.9
| HCB | 0.7 | 7.4 | 91.9
| JPT | 1.8 | 19.5 | 78.8
| YRI | 100.0 | 0.0 | 0.0
| ASW | 94.6 | 3.6 | 1.8
| CHB | 0.7 | 7.4 | 91.9
| CHD | 1.8 | 13.8 | 84.4
| GIH | 39.6 | 43.6 | 16.8
| LWK | 98.2 | 1.8 | 0.0
| MEX | 71.9 | 24.6 | 3.5
| MKK | 98.1 | 1.9 | 0.0
| TSI | 80.2 | 17.8 | 2.0
| HapMapRevision=28
}}
[[rs17822931]], also known as c.538G>A or G180R, is a SNP in the ATP-binding cassette, sub-family C (CFTR/MRP), member 11 [[ABCC11]] gene. The ABCC11 protein helps transport small molecules across apical membranes such as those in apocrine secretory cells. 

{{PMID|16444273}} This SNP determines wet vs dry [[earwax]] as well as sweat production, and it is also associated with lipid secretion. It is commonly (T;T) for Asians and (C;C) for Europeans and Africans.

{{PMID|23325016|OA=1
}} A study of deodorant usage in a large (17,000+) population showed that [[rs17822931]](T;T) individuals were at least 5-fold less likely to use deodorant, consistent with them being "genotypically nonodorous". Although not statistically significant, there was some evidence for a heterozygote effect, implying that individuals with a (C;C) genotype for this SNP were likely to use deodorant at a higher frequency than (C;T) genotypes.

[http://www.gnxp.com/blog/2009/06/ear-wax-to-breast-cancer-risk.php gnxp] indicates this SNP influences risk of [[breast cancer]] in Japanese women. This does not hold true in Caucasian women, though.{{PMID|21655989}}

[http://www.reddit.com/r/askscience/comments/unuym/why_do_asians_have_dry_ear_powder_and_westerners/ reddit discussion] 

{{omim
|id=607040
|desc=ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 11; ABCC11
|rsnum=17822931
}}
{{PMID Auto
|PMID=19650936
|Title=A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene
|OA=1
}}

{{PMID Auto
|PMID=20937735
|Title=The impact of natural selection on an ABCC11 SNP determining earwax type
}}

{{omim
|id=607040
|rsnum=17822931
|variant=0001
}}

{{ClinVar
|rsid=17822931
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=48258198
|CHROM=16
|GMAF=0.3081
|dbSNPBuildID=123
|SSR=0
|SAO=1
|VP=0x05017800000015051f110100
|GENEINFO=ABCC11:85320
|GENE_NAME=ABCC11
|GENE_ID=85320
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000016.9:g.48258198C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=607040.0001
|CLNSIG=5
|CLNCUI=C1861696
|CLNDBN=Apocrine gland secretion, variation in; Axillary odor; Colostrum secretion
|Disease=Apocrine gland secretion; Axillary odor; Colostrum secretion
|CLNACC=RCV000003737.1; RCV000003738.1; RCV000003739.1
|Tags=PM;TPA;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.6915; 0.3085
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1861696:117800
|COMMON=1
}}

{{PMID Auto
|PMID=16255080
|Title=A haplotype map of the human genome.
|OA=1
}}

{{PMID Auto
|PMID=17394018
|Title=A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland.
}}

{{PMID Auto
|PMID=18037328
|Title=Allele frequencies of a SNP and a 27-bp deletion that are the determinant of earwax type in the ABCC11 gene.
}}

{{PMID Auto
|PMID=18817904
|Title=Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies.
|OA=1
}}

{{PMID Auto
|PMID=19737746
|Title=Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation.
|OA=1
}}

{{PMID Auto
|PMID=21423094
|Title=Down-regulation of ABCC11 protein (MRP8) in human breast cancer.
}}

{{GET Evidence
|gene=ABCC11
|aa_change=Gly180Arg
|aa_change_short=G180R
|impact=benign
|qualified_impact=Low clinical importance, Uncertain benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17822931
|overall_frequency_n=1051
|overall_frequency_d=10758
|overall_frequency=0.0976947
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=2
|n_articles_annotated=1
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|qualityscore_in_vitro=1
|qualitycomment_in_vitro=Y
|qualityscore_case_control=5
|qualitycomment_case_control=Y
|qualityscore_familial=5
|qualitycomment_familial=Y
|in_omim=Y
|pph2_score=0.992
|nblosum100=6
|autoscore=3
|webscore=N
|variant_evidence=0
|clinical_importance=0
|summary_short=This variant is associated with dry type ear wax (a benign trait) in a recessive manner.
}}

{{PMID Auto
|PMID=23760047
|Title=The pharmacogenetics of body odor: as easy as ABCC?
}}

{{PMID Auto
|PMID=23970085
|Title=Strong association of the SNP rs17822931 with wet earwax and bromhidrosis in a Chinese family
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}