{{Rsnum
|rsid=17824933
|Gene=CD6
|Chromosome=11
|position=60993140
|Orientation=plus
|GMAF=0.1111
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=CD6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 62.5 | 35.9 | 1.6
| HCB | 97.7 | 2.3 | 0.0
| JPT | 97.8 | 2.2 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 97.7 | 2.3 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs17824933]] is a SNP in the region of the [[CD6]] gene.

A large study (~5,000 patients) found an increased risk for [[multiple sclerosis]] associated with [[rs17824933]]; the odds ratio for the minor allele was reported as 1.18 (CI: 1.07-1.30, p=3.79x10(-9)).{{doi|10.1038/ng.401}}
{{PMID Auto GWAS
|PMID=19525953
|Trait=Multiple sclerosis
|Title=Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
|RiskAllele=G
|Pval=4E-9
|OR=1.18
|ORtxt=[1.07-1.30]
|OA=1
}}

{{PMID Auto
|PMID=19825846
|Title=Genome-wide analysis of allelic expression imbalance in human primary cells by high throughput transcriptome resequencing
|OA=1
}}
{{PMID Auto
|PMID=20430450
|Title=Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain
}}

{{omim
|id=126200
|rsnum=17824933
}}

{{PMID Auto
|PMID=21552549
|Title=The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study
|OA=1
}}
{{PMID Auto
|PMID=20405052
|Title=The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
|OA=1
}}

{{PMID Auto
|PMID=21849685
|Title=The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs17824933
|overall_frequency_n=10
|overall_frequency_d=122
|overall_frequency=0.0819672
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=8
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23638056
|Title=Fine Mapping and Functional Analysis of the Multiple Sclerosis Risk Gene CD6
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}