{{Rsnum
|rsid=17863762
|Gene=UGT1A8
|Chromosome=2
|position=233618537
|Orientation=plus
|GMAF=0.008264
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=UGT1A8
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 7.1 | 92.9
| HCB | 0.7 | 0.0 | 99.3
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.7 | 0.0 | 99.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 1.0 | 1.0 | 98.0
| LWK | 0.9 | 0.0 | 99.1
| MEX | 1.8 | 1.8 | 96.5
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 2.0 | 98.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs17863762
|Name_s=UGT1A8: UGT1A8*3, defined by rs17863762 c.830G>A, mRNA 893G>A, p.Cys277Tyr
|Gene_s=UGT1A8
|Feature=Exon
|Evidence=PubMed ID:12042666
|Annotation=Risk or phenotype-associated allele: UGT1A8*3 (defining allele: 830A, 277Tyr). Phenotype: In vitro catalytic activity and protein expression. Genetic analysis of UGT1A8 (exclusively expressed in extrahepatic tissue) in 69 individuals identified four alleles, of which UGT1A8*3 was defined as having tyrosine at amino acid 277. In vitro studies in HEK293 cells show UGT1A8*3 (830A, 277Y) has a dramatic reduction in catalytic activity compared to wildtype, but no loss in protein expression. Study size: 69. Study population/ethnicity: Lung cancer patients and family members and other volunteers who served as controls. Type of association: GN; FA
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165109784
}}

{{PharmGKB
|RSID=rs17863762
|Name_s=UGT1A8: UGT1A8*1, reference allele, defined as: 173Ala, 255Thr, 277Cys; other definition see PMID: 9535849)
|Gene_s=UGT1A8
|Feature=Exon
|Evidence=PubMed ID:12042666
|Annotation=Risk or phenotype-associated allele: UGT1A8*1 (reference allele defined as: 173Ala, 255Thr, 277Cys; other definition see PMID: 9535849). Phenotype: In vitro catalytic activity and protein expression. Genetic analysis of UGT1A8 (exclusively expressed in extrahepatic tissue) in 69 individuals identified four alleles, of which the reference allele, UGT1A8*1, showed the greatest prevalence (0.55 allele frequency, 39% *1/*1 diplotype, in 71% of all diplotypes) in the population studied, and was defined as having 173Ala, 255Thr, 277Cys. In vitro studies in HEK293 cells show UGT1A8*1 has little impact on function and protein expression. Study size: 69. Study population/ethnicity: Lung cancer patients and family members and other volunteers who served as controls. Type of association: GN; FA
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165109781
}}

{{PMID Auto
|PMID=19572200
|Title=Prediction of deleterious non-synonymous single-nucleotide polymorphisms of human uridine diphosphate glucuronosyltransferase genes.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}