{{Rsnum
|rsid=17879961
|Gene=CHEK2
|Chromosome=22
|position=28725099
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.002296
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CHEK2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 0.0 | 0.0
| HCB | 0.0 | 0.0 | 0.0
| JPT | 0.0 | 1.8 | 98.2
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 3.5 | 96.5
| CHB | 0.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.9 | 99.1
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.6 | 99.4
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}This SNP, a variant in the [[CHEK2]] gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for [[breast cancer]]. {{PMID|17341484}}

For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for [[breast cancer]], refer to the SNPedia [[breast cancer]] entry.

For this particular SNP, the risk (minor) allele is (C).

{{PMID|18086781}} [[rs17879961]] one of 3 SNPs associated with increased risk of [[lung cancer]]

{{omim
|id=604373
|rsnum=17879961
|variant=0002
}}

{{ClinVar
|rsid=17879961
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=29121087
|CHROM=22
|GMAF=0.0023
|dbSNPBuildID=124
|SSR=0
|SAO=1
|VP=0x050268000000040516110100
|GENEINFO=CHEK2:11200
|GENE_NAME=CHEK2
|GENE_ID=11200
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000022.10:g.29121087A>G
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=604373.0002
|CLNSIG=255
|CLNCUI=C1836482
|CLNDBN=Li-Fraumeni syndrome 2; Colorectal cancer, susceptibility to; Cancer of multiple types, susceptibility to; Prostate cancer, susceptibility to
|Disease=Li-Fraumeni syndrome 2; Colorectal cancer; Cancer of multiple types; Prostate cancer
|CLNACC=RCV000005936.1; RCV000005937.1; RCV000005938.1; RCV000005939.1
|Tags=RV;PM;PMC;S3D;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9977; 0.002296
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C1836482:609265:524
|COMMON=1
}}

{{PMID Auto
|PMID=17517688
|Title=Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.
}}

{{PMID Auto
|PMID=19442246
|Title=The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}