{{Rsnum
|rsid=1799724
|Gene=LTA
|Chromosome=6
|position=31574705
|Orientation=plus
|GMAF=0.09734
|Gene_s=LTA,TNF
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}[[rs1799724]], a SNP near the tumor necrosis factor [[TNF]] gene, was found in a study of ~500 Caucasians to be both an independent risk factor for the development of [[Alzheimer's disease]] and also a modifier of the risk for individuals carrying [[ApoE4]] alleles. {{PMID|15895461}}

On its own, the [[rs1799724]](T) allele led to an odds ratio of 1.63 (CI: 1.13-2.34, p=0.009). In carriers of [[ApoE4]] alleles, the odds ratio changed from 2.92 (CI: 2.00-4.27) in the absence of [[rs1799724]](T) to an OR of 6.65 (CI: 3.26-13.55, p=0.03) in its presence. {{PMID|15895461}} 

In a Chinese study {{PMID|18551993}}, post-menopausal women were significantly more likely to have low bone mineral density if they had 
*CC-AA genotypes in [[rs1799724]]-[[rs1800629]]
* a haplotype of [[rs1799724]]-[[rs1800629]]-[[rs6254]]-[[rs6256]]-IL-1ra-[[rs2227956]]-[[rs1801197]]

{{ neighbor
| rsid = 1041981
| distance = 1698
}}
{{ neighbor
| rsid = 361525
| distance = 619
}}

{{ neighbor
| rsid = 1800629
| distance = 549
}}
{{ neighbor
| rsid = 1800750
| distance = 481
}}
{{ neighbor
| rsid = 1799964
| distance = 174
}}

{{ neighbor
| rsid = 1800630
| distance = 6
}}

{{PMID Auto
|PMID=19282863
|Title=Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension
}}

{{omim
|id=191160
|desc=TUMOR NECROSIS FACTOR; TNF
|rsnum=1799724
}}

[http://7thspace.com/headlines/314723/the_role_of_tnf_genetic_variants_and_the_interaction_with_cigarette_smoking_for_gastric_cancer_risk_a_nested_case_control_study.html news] cigarette [[smoking]] and [[gastric cancer]] risk

{{PharmGKB
|RSID=rs1799724
|Name_s=TNF:-850C-T
|Gene_s=LTA, TNF
|Feature=
|Evidence=PubMed ID:11273064
|Annotation=Increased risk of vascular dementia and alzeimer's disease for individuals with a CT or TT genotype.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145118
}}

{{PMID Auto
|PMID=20357201
|Title=Association of Polymorphisms of Tumor Necrosis Factor and Tumor Protein p53 with Primary Open Angle Glaucoma: A Replication Study of Ten Genes in A Chinese Population
}}

{{PharmGKB
|RSID=rs1799724
|Name_s=TNF:?857 C/T
|Gene_s=LTA, TNF
|Feature=
|Evidence=PubMed ID:17450233
|Annotation=Haplotype tagging SNP.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145121
}}
{{PMID Auto
|PMID=21228795
|Title=Impact of LIMK1, MMP2 and TNF-? variations for intracranial aneurysm in Japanese population
}}

{{ population diversity
| geno1 = (C;C)
| geno2 = (C;T)
| geno3 = (T;T)
| CEU | 90.0 | 6.7 | 3.3
| CHB | 68.9 | 24.4 | 6.7
| JPT | 75.6 | 13.3 | 11.1
| YRI | 93.3 | 6.7 | 0.0
}}
{{omim
|id=191160
|rsnum=1799724
|variant=0005
}}

{{PMID Auto
|PMID=21904873
|Title=Association of tumor necrosis factor-? (TNF-?) promoter polymorphisms with overweight/obesity in a Korean population
}}

{{PMID Auto
|PMID=21509504
|Title=Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study
|OA=1
}}

{{PMID Auto
|PMID=12509789
|Title=Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=16449530
|Title=Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=16916584
|Title=Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.
}}

{{PMID Auto
|PMID=17018637
|Title=Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma.
}}

{{PMID Auto
|PMID=17062130
|Title=Polymorphisms within inflammatory genes and colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17355643
|Title=Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.
|OA=1
}}

{{PMID Auto
|PMID=17493155
|Title=Significant association between TNF-alpha (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand.
}}

{{PMID Auto
|PMID=18196539
|Title=TNF polymorphisms and prostate cancer risk.
}}

{{PMID Auto
|PMID=18319718
|Title=Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=18366708
|Title=SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18635873
|Title=TNF promoter polymorphisms associated with muscle phenotypes in humans.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18698679
|Title=Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk.
|OA=1
}}

{{PMID Auto
|PMID=18709160
|Title=Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=18811622
|Title=Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma.
}}

{{PMID Auto
|PMID=18990758
|Title=Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19406964
|Title=Association of genetic variants with chronic kidney disease in Japanese individuals.
|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19615068
|Title=The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19673019
|Title=IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.
|OA=1
}}

{{PMID Auto
|PMID=19673882
|Title=A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.
|OA=1
}}

{{PMID Auto
|PMID=19742166
|Title=Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.
|OA=1
}}

{{PMID Auto
|PMID=19818126
|Title=Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20668555
|Title=Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=20952689
|Title=Cytokine polymorphisms in Th1/Th2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=21385363
|Title=Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=22630053
|Title=Immune regulatory gene polymorphisms as predisposing risk factors for the development of factor VIII inhibitors in Indian severe haemophilia A patients.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1799724
|overall_frequency_n=7
|overall_frequency_d=128
|overall_frequency=0.0546875
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=8
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23086128
|Title=Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer
}}

{{PMID Auto
|PMID=23734748
|Title=Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes
|OA=1
}}

{{PMID Auto
|PMID=23870134
|Title=Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma
|OA=1
}}

{{PMID Auto
|PMID=24003533
|Title=Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects
}}

{{PMID Auto
|PMID=24151497
|Title=Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria
|OA=1
}}

{{PMID Auto
|PMID=24259423
|Title=Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia
}}

{{PMID Auto
|PMID=24405540
|Title=[Association of TNF-1031T/C and clinical efficacy of insulin therapy in newly diagnosed type 2 diabetics]
}}

{{PMID Auto
|PMID=22711844
|Title=SNPs in the TNF-alpha gene promoter associated with Behcet's disease in Moroccan patients.
}}

{{PMID Auto
|PMID=23021043
|Title=Genetics of Behcet's disease in Sardinia: two distinct extended HLA haplotypes harbour the B*51 allele in the normal population and in patients.
}}

{{PMID Auto
|PMID=23071570
|Title=Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.
|OA=1
}}

{{PMID Auto
|PMID=24935328
|Title=Functional tumor necrosis factor alpha polymorphisms and haplotype analysis in high-risk corneal transplantation
}}

{{PMID Auto
|PMID=25083576
|Title=Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study
}}

{{PMID Auto
|PMID=25246119
|Title=Family association study between tumour necrosis factor a gene polymorphisms and polycystic ovary syndrome in Han Chinese
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}