{{Rsnum
|rsid=1799750
|Gene=MMP1
|Chromosome=11
|position=102799765
|Orientation=plus
|GMAF=0.4509
|Gene_s=COX6CP3,MMP1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(-;-)
|geno2=(-;G)
|geno3=(G;G)
}}[[rs1799750]] is a SNP at position -1,607 of the promoter of the [[MMP1]] gene, consisting of an insertion polymorphism.

In a study of ~200 [[breast cancer]] patients, those with [[rs1799750]](G;G) genotype, i.e. also known as the "2G/2G" genotype, had increased frequency of lymph node metastasis and thus a poorer prognosis. The odds ratio for mixed ethnicities was 3.9 (CI: 1.7-9.4, p=0.001), and when calculated only for Caucasians, 2.6 (CI: 1.0-6.9, p=0.06).{{PMID|18006768}}

{{PMID|19508478}} no influence on varicose veins

{{omim
|desc=EPIDERMOLYSIS BULLOSA DYSTROPHICA, AUTOSOMAL RECESSIVE; RDEB
|id=226600
|rsnum=1799750
}}

{{omim
|id=120353
|desc=MATRIX METALLOPROTEINASE 1; MMP1
|rsnum=1799750
}}
{{PMID Auto
|PMID=19681861
|Title=Forty-two novel COL7A1 mutations and the role of a frequent single nucleotide polymorphism in the MMP1 promoter in modulation of disease severity in a large European dystrophic epidermolysis bullosa cohort
}}
{{PMID Auto
|PMID=20038976
|Title=Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma
|OA=1
}}

{{PMID Auto
|PMID=20808730
|Title=Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas
|OA=1
}}
{{PMID Auto
|PMID=21244504
|Title=Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
}}

{{omim
|id=120353
|rsnum=1799750
|variant=0001
}}

{{omim
|id=610504
|rsnum=1799750
}}

{{PMID Auto
|PMID=21410539
|Title=Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture
}}

{{PMID Auto
|PMID=21444408
|Title=Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture
}}

{{PMID Auto
|PMID=16311244
|Title=Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.
}}

{{PMID Auto
|PMID=16356191
|Title=Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=17054776
|Title=The genetics of chronic obstructive pulmonary disease.
|OA=1
}}

{{PMID Auto
|PMID=18787421
|Title=Genetic contributions to disparities in preterm birth.
|OA=1
}}

{{PMID Auto
|PMID=18787887
|Title=Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.
|OA=1
}}

{{PMID Auto
|PMID=18802702
|Title=Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms).
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=19318431
|Title=No association between matrix metalloproteinase-1 or matrix metalloproteinase-3 polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.
|OA=1
}}

{{PMID Auto
|PMID=19321798
|Title=Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis.
|OA=1
}}

{{PMID Auto
|PMID=19379518
|Title=Development of a fingerprinting panel using medically relevant polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19406964
|Title=Association of genetic variants with chronic kidney disease in Japanese individuals.
|OA=1
}}

{{PMID Auto
|PMID=19435861
|Title=No association between matrix metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and endometrial cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19551141
|Title=Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.
|OA=1
}}

{{PMID Auto
|PMID=19664242
|Title=Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.
|OA=1
}}

{{PMID Auto
|PMID=20078883
|Title=Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.
|OA=1
}}

{{PMID Auto
|PMID=20111728
|Title=Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals.
|OA=1
}}

{{PMID Auto
|PMID=20565774
|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{PMID Auto
|PMID=21161369
|Title=Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP) gene and breast cancer risk: a meta-analysis.
}}

{{PMID Auto
|PMID=22388798
|Title=Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
|OA=1
}}

{{PMID Auto
|PMID=23370084
|Title=The MMP1 rs1799750 2G Allele is Associated With Increased Low Back Pain, Sciatica, and Disability After Lumbar Disk Herniation
}}

{{PMID Auto
|PMID=23441116
|Title=Polymorphisms in matrix metalloproteinases MMP1 and MMP9 are associated with primary open-angle and angle closure glaucoma in a Pakistani population
|OA=1
}}

{{PMID Auto
|PMID=22776467
|Title=Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes
}}

{{PMID Auto
|PMID=23497408
|Title=Genetic variants associated with circulating MMP1 levels near matrix metalloproteinase genes on chromosome 11q21-22 in Taiwanese: interaction with obesity
|OA=1
}}

{{PMID Auto
|PMID=23734748
|Title=Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes
|OA=1
}}

{{PMID Auto
|PMID=23813847
|Title=The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and meta-analysis
}}

{{PMID Auto
|PMID=23819551
|Title=Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility
}}

{{PMID Auto
|PMID=15688379
|Title=EBV LMP1 induces the MMP-1 promoter via an Ets binding site formed by a single nucleotide polymorphism - enhanced susceptibility to nasopharyngeal carcinoma
}}

{{PMID Auto
|PMID=24505369
|Title=Matrix Metalloproteinase-1 (MMP-1) Promoter Polymorphisms are Well Linked with Lower Stomach Tumor Formation in Eastern Indian Population
|OA=1
}}

{{PMID Auto
|PMID=23274712
|Title=Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
|OA=1
}}

{{PMID Auto
|PMID=23644943
|Title=Influence of matrix metalloproteinase-1 gene -1607 (1G/2G) (rs1799750) promoter polymorphism on circulating levels of MMP-1 in chronic pancreatitis.
}}

{{PMID Auto
|PMID=25253367
|Title=Role of interstitial collagenase gene promoter polymorphism in the etiology of gastric cancer
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}