{{Rsnum
|rsid=1799782
|Gene=XRCC1
|Chromosome=19
|position=43553422
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.1299
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=XRCC1
}}[[rs1799782]], a SNP also known as Arg194Trp located in the DNA-repair gene [[XRCC1]], is associated with a reduced risk for certain types of [[cancer]]. The (T) allele encodes the Trp amino acid.

A study of ~200 Korean cases of skin [[cancer]] indicated that the [[rs1799782]](T;T) genotype was inversely associated with squamous cell [[cancer]] risk (adjusted odds ratio 0.06, CI: 0.006-0.63).{{PMID|17355263}}

A meta-analysis of 8 case-control studies concluded that significant association was found between the [[rs1799782]] polymorphism and [[oral cancer]] risk among Asians, showing an odds ratio of 1.347 (CI: 1.0 - 1.81) for allele comparison, 1.378 (CI: 1.070 - 1.775) for (T;T) homozygotes vs (C;C) homozygotes, and 1.420 (CI: 1.041 - 1.936) for comparison under a dominant model.{{PMID|19713684}}

18067C>T possibly related to non-Hodgkin lymphoma

{{PMID|18410587}}  [[rs2040639]]-AG, contribute to oral cancer risk. 

pseudo-haplotype with AG-CC genotypes in 
*2.45x risk [[rs2040639]]-[[rs861539]]
*5.03x risk [[rs2040639]]-[[rs861539]]-[[rs2075685]]
*10.10x risk [[rs2040639]]-[[rs861539]]-[[rs2075685]]-[[rs1799782]]

{{PMID|21216841}} A meta-analysis concludes that this SNP is not associated with risk of gastric cancer.

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{{ population diversity
| geno1 = (C;C)
| geno2 = (C;T)
| geno3 = (T;T)
| CEU | 85.0 | 11.7 | 3.3
| CHB | 55.6 | 40.0 | 4.4
| JPT | 51.1 | 42.2 | 6.7
| YRI | 85.0 | 13.3 | 1.7
}}
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{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}