{{Rsnum
|rsid=1799864
|Gene=CCR2
|Chromosome=3
|position=46357717
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.169
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CCR2
}}Compared with individuals without CCR5-Delta32 (a variation in another gene) or [[rs1799864]](A), individuals with one or two copies of [[rs1799864]](A) had a 58% lower risk of developing [[AIDS]] during the first 4 years after testing positive for HIV, a 19% lower risk during the subsequent 4 years, and no significant protection thereafter. {{PMID|12556692}} No protective effect (ie no benefit) was seen for this SNP once [[AIDS]] had developed. {{PMID|11694103}}

{{PMID|19263529|OA=1
}} [[rs1799864]](G), [[rs3025058]](A) and [[rs662]] were associated with increased risk, and [[rs1800775]](A) with reduced risk of recurrent [[venous thromboembolism]]

{{omim
|desc=HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, RESISTANCE TO
|id=601267
|rsnum=1799864
|variant=0001
}}

{{PMID Auto
|PMID=19506371
|Title=Single Nucleotide Polymorphisms in Monocyte Chemoattractant Protein-1 and Its Receptor Act Synergistically to Increase the Risk of Carotid Atherosclerosis
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine
|OA=1
}}

{{PMID Auto
|PMID=20153665
|Title=Genetic variation at the CCR5/CCR2 gene cluster and risk of psoriasis and psoriatic arthritis
}}

{{ population diversity
| geno1 = (A;A)
| geno2 = (A;G)
| geno3 = (G;G)
| CEU | 1.7 | 18.3 | 80.0
| CHB | 2.2 | 44.4 | 53.3
| JPT | 0.0 | 51.1 | 48.9
| YRI | 3.3 | 28.3 | 68.3
}}

{{PMID Auto
|PMID=22733495
|Title=Association of inflammatory chemokine gene CCL2I/D with bladder cancer risk in North Indian population
}}

{{ClinVar
|rsid=1799864
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=46399208
|CHROM=3
|GMAF=0.1685
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050378000000170516110101
|GENEINFO=CCR2:729230
|GENE_NAME=CCR2
|GENE_ID=729230
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000003.11:g.46399208G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=601267.0001
|CLNSIG=5
|CLNCUI=C1836230
|CLNDBN=Congenital human immunodeficiency virus
|Disease=Congenital human immunodeficiency virus
|CLNACC=RCV000008756.1
|Tags=PM;TPA;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.831; 0.169
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1836230:609423
|COMMON=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=17079285
|Title=Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17672867
|Title=Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease.
|OA=1
}}

{{PMID Auto
|PMID=18172114
|Title=Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=18936436
|Title=Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19073967
|Title=Shared and distinct genetic variants in type 1 diabetes and celiac disease.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20031567
|Title=An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20041166
|Title=Common genetic variation and the control of HIV-1 in humans.
|OA=1
}}

{{PMID Auto
|PMID=20552027
|Title=Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.
|OA=1
}}

{{PMID Auto
|PMID=21091093
|Title=Polymorphisms in chemokine and receptor genes and gastric cancer risk and survival in a high risk Polish population.
|OA=1
}}

{{GET Evidence
|gene=CCR2
|aa_change=Val64Ile
|aa_change_short=V64I
|impact=protective
|qualified_impact=Insufficiently evaluated protective
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1799864
|overall_frequency_n=894
|overall_frequency_d=7820
|overall_frequency=0.114322
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|in_omim=Y
|pph2_score=0.001
|nblosum100=-4
|autoscore=2
|webscore=N
|summary_short=Associated with slower HIV disease progression.
}}

{{PMID Auto
|PMID=23427179
|Title=Relationships of Single Nucleotide Polymorphisms of Monocyte Chemoattractant Protein 1 and Chemokine Receptor 2 With Susceptibility and Clinicopathologic Characteristics of Neoplasia of Uterine Cervix in Taiwan Women
}}

{{PMID Auto
|PMID=23632061
|Title=CCR2 and CCR5 genes polymorphisms in benign prostatic hyperplasia and prostate cancer
}}

{{PMID Auto
|PMID=24083412
|Title=Functional Genetic Polymorphisms of Monocyte Chemoattractant Protein 1 and C-C Chemokine Receptor Type 2 in Ischemic Stroke
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}