{{Rsnum
|rsid=1799884
|Gene=GCK
|Chromosome=7
|position=44189469
|Orientation=minus
|GMAF=0.1882
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GCK
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 26.5 | 67.3
| HCB | 4.4 | 34.3 | 61.3
| JPT | 0.0 | 30.1 | 69.9
| YRI | 0.7 | 23.1 | 76.2
| ASW | 7.0 | 24.6 | 68.4
| CHB | 4.4 | 34.3 | 61.3
| CHD | 2.8 | 33.3 | 63.9
| GIH | 0.0 | 23.8 | 76.2
| LWK | 2.7 | 37.3 | 60.0
| MEX | 1.7 | 25.9 | 72.4
| MKK | 7.7 | 32.1 | 60.3
| TSI | 1.0 | 37.3 | 61.8
| HapMapRevision=28
}}
[[rs1799884]], known also as the -30 SNP of the [[GCK]] gene, has been associated with [[type-2 diabetes]].

This SNP is one of 4 relatively common SNPs reported to represent risk for [[type-2 diabetes]] in the DESIR prospective study of 3,877 Caucasian participants. Under a recessive model, the odds ratio for [[rs1799884]](A;A) homozygotes is 2.70 (CI: 1.51-4.83, p=0.0008); under an additive model, the odds ratio is 1.34 (CI: 1.07-1.69, p=0.01). For the 4 SNPs, each risk allele increased [[type-2 diabetes]] risk by 1.34x (p=2x10e-6), with an odds ratio of 2.48 (CI: 1.59-3.86) for carriers of 4 or more compared to those with one or none (risk alleles).{{PMID|17977958}}

{{PMID Auto
|PMID=19241058
|Title=Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.
}}

{{omim
|id=138079
|desc=GLUCOKINASE; GCK
|rsnum=1799884
}}

{{PMID Auto
|PMID=20682688
|Title=Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: common genetic variants in GCK and TCF7L2 are associated with fasting and post-challenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes from the International Association of Diabetes and Pregnancy Study Groups
|OA=1
}}
{{PMID Auto
|PMID=20858683
|Title=Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways
|OA=1
}}

{{omim
|id=613219
|rsnum=1799884
}}

{{PMID Auto GWAS
|PMID=21909109
|Trait=None
|Title=Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
|RiskAllele=A
|Pval=2E-19
|OR=0.0619
|ORtxt=[0.049-0.075] mg/dL increase
}}

{{PMID Auto
|PMID=22716779
|Title=Relevant associations of the glucokinase regulatory protein/glucokinase gene variation with TAG concentrations in a high-cardiovascular risk population: modulation by the Mediterranean diet
}}

{{PMID|17186458|OA=1
}} A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

{{PMID|17503332|OA=1
}} Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.

{{PMID|18332101}} Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.

{{PMID|18498634|OA=1
}} The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

{{PMID|18521185|OA=1
}} Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

{{PMID|18556336|OA=1
}} The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

{{PMID|18689695|OA=1
}} Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

{{PMID|19018513}} The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.

{{PMID|19060907|OA=1
}} Variants in MTNR1B influence fasting glucose levels.

{{PMID|19073768|OA=1
}} Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.

{{PMID|19096518|OA=1
}} Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

{{PMID|19197348|OA=1
}} Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

{{PMID|19368707|OA=1
}} Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.

{{PMID|19533084|OA=1
}} Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.

{{PMID|19741163|OA=1
}} Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose.

{{PMID|19937311}} Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.

{{PMID|20227404}} The glucokinase gene promoter polymorphism -30G>A (rs1799884) is associated with fasting glucose in healthy pregnant women but not with gestational diabetes.

{{PMID|20628598|OA=1
}} Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.

{{PMID|20661421|OA=1
}} Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study.

{{PMID|20668700|OA=1
}} Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.

{{PMID|21697023}} [Fasting hyperglycaemia and polymorphism in glucokinase promoter (rs1799884)].

{{PMID Auto
|PMID=23690305
|Title=Genetic variants and the risk of gestational diabetes mellitus: a systematic review
}}

{{PMID Auto
|PMID=23840762
|Title=Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23575436
  |Trait=Glycemic traits
  |Title=New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.
  |RiskAllele=A
  |Pval=5E-18
  |OR=.06
  |ORtxt=[0.049-0.077] mmol-1 increase
  }}

{{PMID Auto
|PMID=22517333
|Title=Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.
}}

{{PMID Auto
|PMID=22996131
|Title=Monogenic models: what have the single gene disorders taught us?
|OA=1
}}

{{PMID Auto GWAS
  |PMID=24244560
  |Trait=Glycated hemoglobin levels
  |Title=A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.
  |RiskAllele=T
  |Pval=6E-8
  |OR=.44
  |ORtxt=[0.42-0.46] unit increase
  }}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}