{{Rsnum
|rsid = 1799889
|Gene = SERPINE1
|geno1 = (-;-)
|geno2 = (-;G)
|geno3 = (G;G)
|Orientation=plus
|Chromosome=7
|position=101126430
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=SERPINE1
}}[[rs1799889]] is an insertion/deletion polymorphism in the promoter region of the [[SERPINE1]] gene, which is also known as plasminogen activator inhibitor type 1 (or PAI1 or PAI-1). [There are several entries in dbSNP covering this same position; the one here in SNPedia is the one with population frequency.] The most common allele has a run of 5 G's in the area around this SNP, and in the literature the allele is commonly called the 5G allele. A deletion of one nucleotide leads to the "4G" allele, i.e. [[rs1799889(-)]].

The 4G allele has been reported to increase risk for [[atherosclerosis]] and [[coronary artery disease]] {{PMID|9484978}}; on the other hand, the 5G allele may increase the risk of [[abdominal aortic aneurysm]] (AAA). {{PMID|10805895}}

In combination with the A2 allele of the [[ITGB3]] gene, [[rs5918]], the increased risk of [[myocardial infarction]] in a Finnish study population was 4 fold higher (odds ratio = 4.5, p=0.001), particularly in males (odds ratio = 6.4, p=0.0005) {{PMID|9700201}}. 

{{omim
| id = 173360
| variant = 0002
| desc    = PLASMINOGEN ACTIVATOR INHIBITOR POLYMORPHISM
}}
{{ neighbor
| rsid = 1799762
| distance = 2
}}
{{PMID Auto
|PMID=20737565
|Title=Association of PAI-1 gene polymorphism with survival and chemotherapy-related vascular toxicity in testicular cancer
}}

{{PharmGKB
|RSID=rs1799889
|Name_s=
|Gene_s=SERPINE1
|Feature=NA
|Evidence=PubMed ID:18794724
|Annotation=This variant was shown to be assoicated with antidepressant treatment response in a study consisting of 188 Chinese MDD patients and 346 controls.The G allele was less frequent in responders than nonresponders
|Drugs=citalopram; fluoxetine
|Drug Classes=
|Diseases=Depression; Depressive Disorder, Major
|Curation Level=Curated
|PharmGKB Accession ID=PA162370403
}}
{{PMID Auto
|PMID=21752301
|Title=Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head
|OA=1
}}
{{PMID Auto
|PMID=21761413
|Title=Genetic polymorphism of the plasminogen activator inhibitor-1 is associated with an increased risk of endometrial cancer
}}{{PMID|16424345}} Plasminogen activator inhibitor-1 gene: selection of tagging single nucleotide polymorphisms and association with coronary heart disease.

{{PMID|17761618|OA=1
}} 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.

{{PMID|18603647|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

{{PMID|18805939|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

{{PMID|18936436|OA=1
}} Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

{{PMID|19368854}} No association between the promoter polymorphisms of PAI-1 gene and sporadic Alzheimer's disease in Chinese Han population.

{{PMID|19387820|OA=1
}} Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.

{{PMID|19526059|OA=1
}} Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer.

{{PMID|21385363|OA=1
}} Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

{{PMID|21422408}} Clotting factor gene polymorphisms and colorectal cancer risk.

{{PMID|22503724}} Promoter polymorphisms of SERPINE1 are associated with the antidepressant response to depression in Alzheimer's disease.{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1799889
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}
{{PMID Auto
|PMID=23570848
|Title=tPA Alu (I/D) polymorphism associates with bacterial osteomyelitis
}}
{{PMID Auto
|PMID=23941979
|Title=Association of Genetic Polymorphisms With Histological Grading of Necroinflammation, Staging of Fibrosis, and Liver Function in Mexicans With Chronic Hepatitis C Virus Infection
}}
{{PMID Auto
|PMID=24355042
|Title=Association of five common polymorphisms in the plasminogen activator inhibitor-1 gene with primary ovarian insufficiency
}}{{PMID Auto
|PMID=23180602
|Title=Association between the SERPINE1 (PAI-1) 4G/5G insertion/deletion promoter polymorphism (rs1799889) and pre-eclampsia: a systematic review and meta-analysis.
}}
{{PMID Auto
|PMID=25020710
|Title=P324Circadian genes in the regulation of lipids in coronary artery disease
}}
{{PMID Auto
|PMID=25231632
|Title=Pai-1 Gene Variants and COC Use Are Associated with Stroke Risk: A Case-Control Study in the Han Chinese Women
}}