{{Rsnum
|rsid=1799969
|Gene=ICAM1
|Chromosome=19
|position=10284116
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.07071
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ICAM1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 19.6 | 80.4
| HCB | 0.0 | 0.7 | 99.3
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 1.8 | 98.2
| CHB | 0.0 | 0.7 | 99.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 7.9 | 92.1
| LWK | 0.0 | 0.0 | 0.0
| MEX | 1.7 | 32.8 | 65.5
| MKK | 0.0 | 0.6 | 99.4
| TSI | 0.0 | 16.7 | 83.3
| HapMapRevision=28
}}
[[rs1799969]], also known as G241R or +241G/A, is a SNP in the [[ICAM1]] gene. The more common (G) allele encodes the glycine (G).

A study of 276 Iranian [[breast cancer]] patients concluded (p = 0.008) that [[rs1799969]](A) allele carriers may have a higher risk of developing [[breast cancer]].{{PMID|18474291}}

{{ neighbor
| rsid = 5498
| distance = 891
}}

{{GWAS Summary
|SNP=rs1799969
|PubMedID=18604267
|Condition=Soluble ICAM-1
|Gene=ICAM1
|Risk Allele=G
|pValue=4.00E-047
|OR=28.19
|95CI=NR) umol/L decreas
|OA=1
}}
{{PMID Auto
|PMID=19332210
|Title=Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: Data from the Women's Genome Health Study
|OA=1
}}

{{PMID Auto
|PMID=18420209
|Title=ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)
|OA=1
}}

{{PharmGKB
|RSID=rs1799969
|Name_s=
|Gene_s=ICAM1, ICAM5, ICAM4
|Feature=
|Evidence=PubMed ID:18604267; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women (Initial Sample Size: 4,570 women; Replication Sample Size: 2,008 women; Risk Allele: rs1799969-G). This variant is associated with Soluble ICAM-1.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Malaria; Myocardial Infarction; Stroke
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356564
}}
{{PMID Auto
|PMID=20031590
|Title=The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations
|OA=1
}}

{{PMID Auto
|PMID=20585554
|Title=On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study
|OA=1
}}
{{PMID Auto
|PMID=21245421
|Title=Genetic Factors Underlying the Risk of Thalidomide-Related Neuropathy in Patients With Multiple Myeloma
}}

{{PMID Auto GWAS
|PMID=21533024
|Trait=None
|Title=Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
|RiskAllele=A
|Pval=1E-120
|OR=24.9000
|ORtxt=[NR] ng/mL decrease
|OA=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=16385446
|Title=A testing framework for identifying susceptibility genes in the presence of epistasis.
|OA=1
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=17903293
|Title=Genome-wide association with select biomarker traits in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=18045485
|Title=The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18505543
|Title=Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=18528404
|Title=Variation in the ICAM1 gene is not associated with severe malaria phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18703101
|Title=ICAM1 R241 is not associated with celiac disease in the Spanish population.
}}

{{PMID Auto
|PMID=18778477
|Title=Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=22388798
|Title=Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
|OA=1
}}

{{GET Evidence
|gene=ICAM1
|aa_change=Gly241Arg
|aa_change_short=G241R
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1799969
|overall_frequency_n=812
|overall_frequency_d=10758
|overall_frequency=0.0754787
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|pph2_score=0.948
|nblosum100=6
|autoscore=3
|webscore=N
}}

{{PMID Auto
|PMID=24289603
|Title=Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}