{{Rsnum
|rsid=1800169
|Gene=CNTF
|Chromosome=11
|position=58624028
|Orientation=plus
|GMAF=0.1244
|Gene_s=CNTF,FAM75C1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.4 | 22.1 | 73.5
| HCB | 1.5 | 24.8 | 73.7
| JPT | 3.5 | 20.4 | 76.1
| YRI | 0.7 | 4.8 | 94.6
| ASW | 0.0 | 8.8 | 91.2
| CHB | 1.5 | 24.8 | 73.7
| CHD | 0.9 | 26.6 | 72.5
| GIH | 3.0 | 25.7 | 71.3
| LWK | 0.0 | 3.6 | 96.4
| MEX | 3.4 | 37.9 | 58.6
| MKK | 0.6 | 12.2 | 87.2
| TSI | 3.9 | 25.5 | 70.6
| HapMapRevision=28
}}[[rs1800169]] is a SNP in the ciliary neurotrophic factor [[CNTF]] gene.

In a study of 417 patients with [[schizophrenia]], 279 were treated with [[iloperidone]] while 138 were treated with placebo. [[Iloperidone]] significantly improved in 6 clinical scores versus placebo. [[rs1800169]](G;G) homozygotes showed greater improvement with [[iloperidone]] compared to placebo for 3 of the clinical scores compared to carriers of a [[rs1800169]](A) allele.{{PMID|18303965}}

{{PMID Auto
|PMID=19833146
|Title=Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain
}}

{{PharmGKB
|RSID=rs1800169
|Name_s=CNTF: FS63TER, null
|Gene_s=CNTF, ZFP91, ZFP91-CNTF
|Feature=
|Evidence=PubMed ID:18303965
|Annotation=Schizophrenia patients with homozygous G/G for the rs1800169 show better response to iloperidone.
|Drugs=iloperidone
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161615729
}}

{{PMID Auto
|PMID=16696750
|Title=Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women.
}}

{{PMID Auto
|PMID=20368905
|Title=New atypical antipsychotics for schizophrenia: iloperidone.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800169
|overall_frequency_n=1210
|overall_frequency_d=10758
|overall_frequency=0.112474
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}