{{Rsnum
|rsid=1800206
|Gene=PPARA
|Chromosome=22
|position=46218377
|Orientation=plus
|GMAF=0.02479
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PPARA
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 92.3 | 7.7 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{omim
|id=170998
|rsnum=1800206
|variant=0001
}}

{{ClinVar
|rsid=1800206
|Reversed=0
|FwdREF=C
|FwdALT=G
|REF=C
|ALT=G
|RSPOS=46614274
|CHROM=22
|GMAF=0.0252
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050178000000150517110100
|GENEINFO=PPARA:5465
|GENE_NAME=PPARA
|GENE_ID=5465
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000022.10:g.46614274C>G
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;TPA;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9752; 0.02479
|CLNACC=RCV000014700.1
|CLNDBN=Hyperapobetalipoproteinemia, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=170998.0001
|COMMON=1
|Disease=Hyperapobetalipoproteinemia
}}

{{PMID Auto
|PMID=17317762
|Title=Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
}}

{{PMID Auto
|PMID=17850927
|Title=The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association.
}}

{{PMID Auto
|PMID=18304332
|Title=No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.
|OA=1
}}

{{PMID Auto
|PMID=18401448
|Title=PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease.
|OA=1
}}

{{PMID Auto
|PMID=18541586
|Title=Peroxisome proliferator-activated receptor [alpha] genetic variation interacts with n-6 and long-chain n-3 fatty acid intake to affect total cholesterol and LDL-cholesterol concentrations in the Atherosclerosis Risk in Communities Study.
|OA=1
}}

{{PMID Auto
|PMID=18549840
|Title=Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke.
|OA=1
}}

{{PMID Auto
|PMID=18586686
|Title=Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study.
|OA=1
}}

{{PMID Auto
|PMID=18855529
|Title=Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19223982
|Title=Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis.
|OA=1
}}

{{PMID Auto
|PMID=20414453
|Title=PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=21430558
|Title=Association of the peroxisome proliferator-activated receptor alpha gene L162V polymorphism with stage C heart failure.
}}

{{PMID Auto
|PMID=21487230
|Title=Effects of peroxisome proliferator-activated receptors, dietary fat intakes and gene-diet interactions on peak particle diameters of low-density lipoproteins.
}}

{{PMID Auto
|PMID=22378291
|Title=PPARgamma2 gene Pro12Ala and PPARalpha gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations.
}}

{{PMID Auto
|PMID=22968028
|Title=[Association of both peroxisome proliferator-activated receptor, gene-gene interactions and the body mass index]
}}

{{GET Evidence
|gene=PPARA
|aa_change=Leu162Val
|aa_change_short=L162V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800206
|overall_frequency_n=485
|overall_frequency_d=10758
|overall_frequency=0.0450827
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=6
|n_articles_annotated=6
|qualityscore_in_vitro=2
|qualityscore_treatability=1
|in_omim=Y
|pph2_score=0.013
|nblosum100=0
|autoscore=2
|webscore=N
|summary_short=May be associated with the development of stage C heart failure. 
}}

{{PMID Auto
|PMID=23262340
|Title=Gene-gene interactions among PPARα/δ/γ polymorphisms for hypertriglyceridemia in Chinese Han population
}}

{{PMID Auto
|PMID=23545576
|Title=Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population
|OA=1
}}

{{PMID Auto
|PMID=23937834
|Title=[Effects related to gene-gene interactions of peroxisome proliferator-activated receptor on essential hypertension]
}}

{{PMID Auto
|PMID=24232815
|Title=Influence of PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms on the lipid-lowering efficacy and safety of statin therapy
}}

{{PMID Auto
|PMID=23363867
|Title=[Gene-gene interactions among the peroxisome proliferator-activated receptor polymorphisms for hypertriglyceridemia]
}}

{{PMID Auto
|PMID=22920733
|Title=Investigation of endocannabinoid system genes suggests association between peroxisome proliferator activator receptor-alpha gene (PPARA) and schizophrenia.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}