{{Rsnum
|rsid=1800255
|Gene=COL3A1
|Chromosome=2
|position=188999354
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.2094
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=COL3A1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 36.9 | 56.9
| HCB | 2.2 | 35.6 | 62.2
| JPT | 6.4 | 46.8 | 46.8
| YRI | 0.0 | 22.2 | 77.8
| ASW | 0.0 | 12.7 | 87.3
| CHB | 2.2 | 35.6 | 62.2
| CHD | 5.7 | 36.2 | 58.1
| GIH | 9.1 | 39.4 | 51.5
| LWK | 0.0 | 14.3 | 85.7
| MEX | 10.7 | 28.6 | 60.7
| MKK | 0.0 | 14.6 | 85.4
| TSI | 2.0 | 45.5 | 52.5
| HapMapRevision=28
}}
[[rs1800255]] is a SNP in the alpha I chain of the type III collagen protein-encoding [[COL3A1]] gene.

A relatively small study (200 patients) reported an odds ratio of 5 (CI: 1.4-17.1) between [[rs1800255]](A;A) homozygotes and risk for [[pelvic organ prolapse]]. No significance was found for the heterozygous genotype.{{PMID|19444361}}

{{omim
|id=120180
|rsnum=1800255
|variant=0007
}}

{{PMID Auto
|PMID=22241462
|Title=A functional variant of the collagen type III alpha1 gene modify risk of sporadic intracranial aneurysms
}}

{{ClinVar
|rsid=1800255
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=189864080
|CHROM=2
|GMAF=0.2088
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x05016800000015051f110101
|GENEINFO=COL3A1:1281
|GENE_NAME=COL3A1
|GENE_ID=1281
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.189864080G>A
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7906; 0.2094
|CLNACC=RCV000018745.1
|CLNDBN=COLLAGEN TYPE III POLYMORPHISM
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=120180.0007
|COMMON=1
|Disease=COLLAGEN TYPE III POLYMORPHISM
}}

{{PMID Auto
|PMID=18642782
|Title=[Correlation of COL3A1 gene with type III collagen stability in intracranial aneurysm].
}}

{{PMID Auto
|PMID=18722615
|Title=Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse.
}}

{{PMID Auto
|PMID=19398442
|Title=Collagen type III alpha I is a gastro-oesophageal reflux disease susceptibility gene and a male risk factor for hiatus hernia.
|OA=1
}}

{{PMID Auto
|PMID=21219851
|Title=A novel mutation screening system for Ehlers-Danlos Syndrome, vascular type by high-resolution melting curve analysis in combination with small amplicon genotyping using genomic DNA.
}}

{{PMID Auto
|PMID=23013106
|Title=No association between COL3A1, COL6A1 or COL12A1 gene variants and range of motion
}}

{{GET Evidence
|gene=COL3A1
|aa_change=Ala698Thr
|aa_change_short=A698T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800255
|overall_frequency_n=2268
|overall_frequency_d=10758
|overall_frequency=0.21082
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=1
|autoscore=3
|n_web_uneval=1
}}

{{PMID Auto
|PMID=22894972
|Title=Collagen genes and exercise-associated muscle cramping
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}