{{Rsnum
|rsid=1800437
|Gene=GIPR
|Chromosome=19
|position=45678134
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.1818
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=GIPR
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 4.6 | 26.2 | 69.2
| HCB | 6.7 | 26.7 | 66.7
| JPT | 0.0 | 45.5 | 54.5
| YRI | 0.0 | 14.3 | 85.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 6.7 | 26.7 | 66.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}SNP [[rs1800437]], located in the coding region of the [[GIPR]] gene and known as Glu354Gln, shows a marginal association with cardiovascular disease (CVD) in a study of ~200 patients from a Dutch population. Heterozygotes are reported to be at lower risk for CVD, with an odds ratio of 0.72 (CI: 0.52 - 0.97, p=0.03). However, no significant association was seen for homozygous carriers of the minor allele. {{PMID|17624916}}

{{PMID Auto
|PMID=19254363
|Title=Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups.
|OA=1
}}

{{PMID Auto
|PMID=20081857
|Title=Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|OA=1
}}

{{PMID Auto
|PMID=20516203
|Title=Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin.
}}

{{GET Evidence
|gene=GIPR
|aa_change=Glu354Gln
|aa_change_short=E354Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800437
|overall_frequency_n=1883
|overall_frequency_d=10758
|overall_frequency=0.175033
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.988
|nblosum100=-2
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23563607
  |Trait=Obesity
  |Title=Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
  |RiskAllele=G
  |Pval=3E-14
  |OR=1.10
  |ORtxt=[NR]
  |OA=1
}}

{{PMID Auto
|PMID=24446656
|Title=A Functional Amino Acid Substitution in the Glucose-dependent Insulinotropic Polypeptide-Receptor (GIPR) Gene is Associated with Lower Bone Mineral Density and Increased Fracture risk
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}