{{Rsnum
|rsid=1800458
|Gene=TTR
|Chromosome=18
|position=31592902
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.03398
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TTR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 18.6 | 81.4
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 1.8 | 98.2
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 1.0 | 99.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 6.9 | 93.1
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 7.8 | 92.2
| HapMapRevision=28
}}{{omim
|desc=TRANSTHYRETIN SER-6 POLYMORPHISM
|id=176300
|rsnum=1800458
|variant=0036
}}

{{ neighbor
| rsid = 28933979
| distance = 72
}}

{{ClinVar
|rsid=1800458
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=29172865
|CHROM=18
|GMAF=0.0339
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x05037800000015051f110100
|GENEINFO=TTR:7276
|GENE_NAME=TTR
|GENE_ID=7276
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000018.9:g.29172865G>A
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.966; 0.03398
|CLNACC=RCV000014394.1; RCV000036379.2
|CLNDBN=TRANSTHYRETIN POLYMORPHISM; AllHighlyPenetrant
|CLNDSDB=MedGen
|CLNDSDBID=CN169374
|CLNSRC=Emory University; OMIM Allelic Variant
|CLNSRCID=10683; 176300.0036
|COMMON=1
|Disease=TRANSTHYRETIN POLYMORPHISM; AllHighlyPenetrant
}}

{{PMID|16716350}} Transthyretin: no association between serum levels or gene variants and schizophrenia.

{{PMID|19328595|OA=1
}} Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.

{{GET Evidence
|gene=TTR
|aa_change=Gly26Ser
|aa_change_short=G26S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800458
|overall_frequency_n=604
|overall_frequency_d=10758
|overall_frequency=0.0561443
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=3
|n_web_uneval=9
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}