{{Rsnum
|rsid=1800532
|Gene=TPH1
|Chromosome=11
|position=18026269
|Orientation=minus
|GMAF=0.3581
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=TPH1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 23.9 | 41.6 | 34.5
| HCB | 21.2 | 43.8 | 35.0
| JPT | 28.3 | 50.4 | 21.2
| YRI | 4.1 | 18.4 | 77.6
| ASW | 1.8 | 35.1 | 63.2
| CHB | 21.2 | 43.8 | 35.0
| CHD | 18.3 | 54.1 | 27.5
| GIH | 9.9 | 42.6 | 47.5
| LWK | 0.0 | 16.4 | 83.6
| MEX | 15.5 | 41.4 | 43.1
| MKK | 1.3 | 19.2 | 79.5
| TSI | 10.8 | 48.0 | 41.2
| HapMapRevision=28
}}
commonly referred to as A218C

[[rs211105]], [[rs1800532]] and [[rs7933505]] related to [[schizophrenia]]

{{ neighbor
| rsid = 1799913
| distance = 561
}}

{{omim
|desc=SCHIZOPHRENIA; SCZD
|id=181500
|rsnum=1800532
}}

{{omim
|desc=TRYPTOPHAN HYDROXYLASE 1; TPH1
|id=191060
|rsnum=1800532
}}
{{PMID Auto
|PMID=19590397
|Title=5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression
}}

{{PMID Auto
|PMID=20043001
|Title=Risk-Taking Behavior in a Gambling Task Associated with Variations in the Tryptophan Hydroxylase 2 Gene: Relevance to Psychiatric Disorders
|OA=1
}}

{{PMID Auto
|PMID=20144688
|Title=Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population
}}

{{PMID Auto
|PMID=20421849
|Title=Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene (GRIN2B)
}}
{{PMID Auto
|PMID=20945066
|Title=TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients
}}

{{PMID Auto
|PMID=21989108
|Title=Interaction between tryptophan hydroxylase I polymorphisms and childhood abuse is associated with increased risk for borderline personality disorder in adulthood
|OA=1
}}

{{PMID Auto
|PMID=15206000
|Title=Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway.
}}

{{PMID Auto
|PMID=15799788
|Title=Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan.
|OA=1
}}

{{PMID Auto
|PMID=17483451
|Title=Gene-gene interaction associated with neural reward sensitivity.
|OA=1
}}

{{PMID Auto
|PMID=17521439
|Title=Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach.
|OA=1
}}

{{PMID Auto
|PMID=18782386
|Title=Tryptophan hydroxylase 2 gene and alcohol use among college students.
|OA=1
}}

{{PMID Auto
|PMID=19258022
|Title=Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.
|OA=1
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=20008943
|Title=Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
|OA=1
}}

{{PMID Auto
|PMID=20580984
|Title=Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21601290
|Title=Association between the TPH1 A218C polymorphism and risk of mood disorders and alcohol dependence: evidence from the current studies.
}}

{{PMID Auto
|PMID=23221997
|Title=TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression
}}

{{PMID Auto
|PMID=23499153
|Title=Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy
}}

{{PMID Auto
|PMID=23032942
|Title=The association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=23313272
|Title=An association study of suicide and candidate genes in the serotonergic system.
}}

{{PMID Auto
|PMID=23733030
|Title=Pharmacogenetics in major depression: a comprehensive meta-analysis.
}}

{{PMID Auto
|PMID=23172723
|Title=TPH gene polymorphisms are associated with disease perception and quality of life in women with irritable bowel syndrome
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}