{{Rsnum
|rsid=1800587
|Gene=IL1A
|Chromosome=2
|position=112785383
|Orientation=minus
|GMAF=0.253
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL1A
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 56.6 | 36.3 | 7.1
| HCB | 86.9 | 13.1 | 0.0
| JPT | 79.6 | 18.6 | 1.8
| YRI | 30.6 | 49.7 | 19.7
| ASW | 35.7 | 58.9 | 5.4
| CHB | 86.9 | 13.1 | 0.0
| CHD | 86.2 | 13.8 | 0.0
| GIH | 48.5 | 42.6 | 8.9
| LWK | 36.4 | 51.8 | 11.8
| MEX | 55.2 | 39.7 | 5.2
| MKK | 47.1 | 36.1 | 16.8
| TSI | 54.9 | 36.3 | 8.8
| HapMapRevision=28
}}
{{Report GE
|PubMed=17471097
|Source=
|AffyProbeset=SNP_A-8486970
|AffyOrientation=same
|AlleleA=C
|AlleleB=T
|onGW5=0
|rsid=1800587
|ancestral=C
|RiskPopulation=Caucasian
|RiskAllele=T
|CaseFreq=
|ControlFreq=
|OddsRatioHet=1.31
|OddsRatioHom=7.87
|OddsRatioAll=
|Disease=Intervertebral disc disease
|DiseaseSymbol=IDD
}}

[[rs1800587]], also known as C-889T, is a SNP in the IL-1 alpha [[IL1A]] gene.

A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that [[rs1800587]](T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of [[obesity]] or inflammatory markers. {{PMID|18716798}}

[[rs1800587]] increases susceptibility to Intervertebral disc disease 1.31 times for (C;T) heterozygotes and 7.87 times for (T;T) homozygotes {{PMID|17471097}}

This SNP has also been reported to be associated with Alzheimer's disease in a few studies, but probably ruled out in even more studies, such as this one {{PMID|19158434}}.

{{PMID Auto
|PMID=19619703
|Title=Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study
|OA=1
}}

{{PMID Auto
|PMID=20157068
|Title=Association of IL1A, IL1B, and TNF Gene Polymorphisms With Chronic Rhinosinusitis With and Without Nasal Polyposis: A Replication Study
}}

{{PMID Auto
|PMID=20565898
|Title=Association of IL1A and IL1B loci with primary open angle glaucoma
|OA=1
}}
{{PMID Auto
|PMID=20116409
|Title=The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis
}}
{{PMID Auto
|PMID=21070631
|Title=The dopamine beta-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
|OA=1
}}

{{PMID Auto
|PMID=21637534
|Title=Interleukin-8-251T &gt; A, Interleukin-1?-889C &gt; T and Apolipoprotein E polymorphisms in Alzheimer's disease
|OA=1
}}

{{PMID Auto
|PMID=22216303
|Title=Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice
|OA=1
}}

{{PMID Auto
|PMID=21672595
|Title=Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis
}}

{{PMID Auto
|PMID=22285486
|Title=Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis
}}

{{PMID Auto
|PMID=21509504
|Title=Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study
|OA=1
}}

{{PMID|15726497|OA=1
}} Gene-environment interaction effects on the development of immune responses in the 1st year of life.

{{PMID|16078996|OA=1
}} Association study of functional genetic variants of innate immunity related genes in celiac disease.

{{PMID|16519819|OA=1
}} Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

{{PMID|16617143|OA=1
}} Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.

{{PMID|16719905|OA=1
}} Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.

{{PMID|16820586|OA=1
}} Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

{{PMID|16916584}} Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.

{{PMID|17205326}} The effect of interleukin-1alpha polymorphisms on bone mineral density and the risk of vertebral fractures.

{{PMID|17327408|OA=1
}} Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

{{PMID|17459217}} [A meta-analysis on interleukin-1 gene cluster polymorphism and genetic susceptibility for ankylosing spondylitis].

{{PMID|17705862|OA=1
}} Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

{{PMID|18576312|OA=1
}} A broad analysis of IL1 polymorphism and rheumatoid arthritis.

{{PMID|18603647|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

{{PMID|18633131|OA=1
}} Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

{{PMID|18676870|OA=1
}} Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

{{PMID|19035492|OA=1
}} Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis.

{{PMID|19043479|OA=1
}} Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

{{PMID|19066394|OA=1
}} Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

{{PMID|19131662|OA=1
}} A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

{{PMID|19155622}} Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease.

{{PMID|19263529|OA=1
}} Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

{{PMID|19330901|OA=1
}} Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

{{PMID|19559392|OA=1
}} A candidate gene association study of 77 polymorphisms in migraine.

{{PMID|19742166|OA=1
}} Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

{{PMID|20031567|OA=1
}} An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

{{PMID|20192980}} The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.

{{PMID|20196868|OA=1
}} Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

{{PMID|20347268}} Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population.

{{PMID|20353565|OA=1
}} Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.

{{PMID|20574532|OA=1
}} Intermediate phenotypes identify divergent pathways to Alzheimer's disease.

{{PMID|20811626|OA=1
}} Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

{{PMID|20934174}} Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians.

{{PMID|21205020}} Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.

{{PMID|21385326}} Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease.

{{PMID|22035161}} Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.

{{PMID|22341060}} Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1beta polymorphism.

{{PMID Auto
|PMID=23050050
|Title=Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up
|OA=1
}}

{{PMID Auto
|PMID=22723975
|Title=Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study
|OA=1
}}

{{PMID Auto
|PMID=23216199
|Title=Associations of the interleukin-1 gene locus polymorphisms with risk to hip and knee osteoarthritis: gender and subpopulation differences
}}

{{PMID Auto
|PMID=24103372
|Title=Interleukin-1 alpha (rs1800587) genetic polymorphism is associated with specific cognitive functions but not depression or loneliness in elderly males without dementia
}}

{{PMID Auto
|PMID=24357513
|Title=The variant interleukin 1f7 rs3811047 G&gt;A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population
}}

{{PMID Auto
|PMID=24460370
|Title=Relationship Between IL1 Gene Polymorphisms and Periodontal Disease in Japanese Women
}}

{{PMID Auto
|PMID=24477584
|Title=Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population
}}

{{PMID Auto
|PMID=21962386
|Title=The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.
}}

{{PMID Auto
|PMID=22623017
|Title=Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge.
}}

{{PMID Auto
|PMID=22925444
|Title=Genetic and immunological markers predict titanium implant failure: a retrospective study.
}}

{{PMID Auto
|PMID=23459936
|Title=Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=23594042
|Title=Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.
}}

{{PMID Auto
|PMID=23722873
|Title=Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}