{{Rsnum
|rsid=1800588
|Gene=LIPC
|Chromosome=15
|position=58431476
|Orientation=plus
|GMAF=0.3646
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=LIPC,LOC102724766
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 56.9 | 35.4 | 7.7
| HCB | 35.6 | 51.1 | 13.3
| JPT | 15.9 | 50.0 | 34.1
| YRI | 20.6 | 52.4 | 27.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 35.6 | 51.1 | 13.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs1800588]], also known as the -514C/T polymorphism of the [[LIPC]] gene, may influence the levels of the "good" cholestorols, the high density lipoprotein (HDL) cholesterols. Generally, the (T) allele (as published) is considered to lead to higher HDL levels.

However, high HDL cholesterol, at least when combined with another HDL raising SNP ([[rs708272]]), doesn't appear to actually protect individuals from [[coronary artery disease]], at least based on one study of ~800 Caucasian male patients. {{PMID|18164013}}

{{PMID Auto GWAS
|PMID=18193044
|Trait=HDL cholesterol
|Title=Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
|RiskAllele=T
|Pval=2.0000000000000001E-32
|OR=0.14
|ORtxt=[0.12-0.16]% SD higher
|OA=1
}}

{{PMID Auto
|PMID=19558527
|Title=Hepatic lipase promoter C-480T polymorphism (a synonym for -514C/T) is associated with serum lipids levels, but not subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study
}}

{{PMID Auto
|PMID=20075193
|Title=A genome-wide linkage scan identifies multiple QTLs for HDL cholesterol levels in families with premature CAD and MI
|OA=1
}}

{{PMID Auto
|PMID=19773416
|Title=A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women
|OA=1
}}
{{PMID Auto
|PMID=21252145
|Title=Physical Activity Modifies the Effect of LPL, LIPC and CETP Polymorphisms on HDL-C Levels and the Risk of Myocardial Infarction in Caucasian Women
|OA=1
}}

{{PMID Auto
|PMID=21149302
|Title=Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
|OA=1
}}

{{PMID|17157861|OA=1
}} Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults.

{{PMID|17903299|OA=1
}} A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.

{{PMID|18275964|OA=1
}} Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study.

{{PMID|18513389|OA=1
}} New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.

{{PMID|18660489}} Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

{{PMID|19041386|OA=1
}} Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

{{PMID|19060910|OA=1
}} Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

{{PMID|19101670|OA=1
}} LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.

{{PMID|19131662|OA=1
}} A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

{{PMID|19148283|OA=1
}} Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

{{PMID|19185284|OA=1
}} Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.

{{PMID|19263529|OA=1
}} Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

{{PMID|19336475|OA=1
}} Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

{{PMID|19379518|OA=1
}} Development of a fingerprinting panel using medically relevant polymorphisms.

{{PMID|19435741|OA=1
}} Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.

{{PMID|19557453|OA=1
}} beta-Carotene conversion products and their effects on adipose tissue.

{{PMID|19734193|OA=1
}} Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.

{{PMID|19802338|OA=1
}} Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.

{{PMID|19822575|OA=1
}} Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.

{{PMID|19951432|OA=1
}} Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

{{PMID|20018036|OA=1
}} Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.

{{PMID|20565774|OA=1
}} Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

{{PMID|21347282|OA=1
}} Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

{{PMID|22294764|OA=1
}} Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800588
|overall_frequency_n=1411
|overall_frequency_d=4586
|overall_frequency=0.307676
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23262498
|Title=Impact of geneticfactorsondyslipidemia in HIV-infected patients starting antiretroviral therapy
}}

{{PMID Auto
|PMID=24426196
|Title=Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study
|OA=1
}}

{{PMID Auto
|PMID=22935046
|Title=A high carbohydrate diet induces the beneficial effect of the CC genotype of hepatic lipase C-514T polymorphism on the apoB100/apoAI ratio only in young Chinese males.
}}

{{PMID Auto
|PMID=23021345
|Title=Gene-diet interactions on plasma lipid levels in the Inuit population.
}}

{{PMID Auto
|PMID=23372063
|Title=Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels.
}}

{{PMID Auto
|PMID=23550552
|Title=Association of hepatic lipase gene polymorphisms with hypertriglyceridemia and low high-density lipoprotein-cholesterol levels among South Indian subjects without diabetes.
}}

{{PMID Auto
|PMID=25020710
|Title=P324Circadian genes in the regulation of lipids in coronary artery disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}