{{Rsnum
|rsid=1800629
|Gene=TNF
|Chromosome=6
|position=31575254
|Orientation=plus
|GMAF=0.0955
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TNF
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 1.8 | 31.0 | 67.3
| HCB | 0.7 | 15.3 | 83.9
| JPT | 0.0 | 4.4 | 95.6
| YRI | 0.7 | 17.7 | 81.6
| ASW | 0.0 | 12.3 | 87.7
| CHB | 0.7 | 15.3 | 83.9
| CHD | 0.0 | 8.3 | 91.7
| GIH | 1.0 | 8.9 | 90.1
| LWK | 0.0 | 17.3 | 82.7
| MEX | 0.0 | 12.1 | 87.9
| MKK | 0.6 | 14.7 | 84.6
| TSI | 0.0 | 18.6 | 81.4
| HapMapRevision=28
}}
{{ neighbor
| rsid = 1799724
| distance = 549
}}
{{ neighbor
| rsid = 361525
| distance = 70
}}
{{ neighbor
| rsid = 1800750
| distance = 68
}}

This SNP in the [[tumor necrosis factor]]-alpha gene, [[rs1800629]], is also known as the [[TNF]]-308 SNP. Occasionally the [[rs1800629]](A) allele is referred to as 308.2 or TNF2, with the more common (G) allele being 308.1 or TNF1. The (A) allele is associated with higher levels of TNF expression. This SNP has been linked to a wide variety of conditions:

* [[Allograft rejection]]
** Among 72 Polish patients receiving a kidney transplant, the risk of acute kidney allograft rejection was 2.5x higher among [[rs1800629]](A) carriers compared to (G;G) homozygotes (CI: 1.19- 5.37, p<.05). {{PMID|15964333}}

* [[Asthma]]
** A meta-analysis of ~2,500 patients combined indicated that the [[rs1800629]](A) allele was associated with a 1.46x increased risk for [[asthma]]. {{PMID|16865291}}
** In a study of ~600 Mexican families and their asthmatic children, [[rs1800629]](A) carriers had an increased risk of [[asthma]] (relative risk = 1.54, CI: 1.04-2.28), especially among children of non-smoking parents (odds then 2.06, CI: 1.19-3.55, p for interaction = 0.09). {{PMID|17450233|OA=1
}}
** In a study of Norwegian children, nonallergic [[asthma]] was associated with [[rs1800629]](A) carriers (odds ratio 1.7, CI: 1.3-2.3). {{PMID|17686102}}

* [[Chronic obstructive pulmonary disease]]
** A meta-analysis of 36 publications totaling ~5,000 patients concluded that the association between the [[rs1800629]](A) allele and the risk of COPD was statistically significant for Asians (odds ratio 2.36, CI: 1.84 - 3.02, p < 0.0001) but not for Caucasians.{{PMID|20946339}}

* [[Crohn's disease]]
** In a study of 235 Portuguese patients, the [[rs1800629]](A;A) genotype was associated with higher susceptibility to [[Crohn's disease]], with an odds ratio of 3.0 (CI: 1.2-7.2). These homozygotes also showed more disease-related complications. {{PMID|15803022}}

* Exfoliation [[glaucoma]] (XFG)
** A study of 204 patients with exfoliation glaucoma (XFG) concluded that [[rs1800629]] is unlikely to be a major risk factor for XFG in Caucasians. [{{PMID|19279689|OA=1
}}]

* [[Graves' disease]]
** A meta-analysis of 10 case-control studies, including over 2,200 [[Graves' disease]] cases, concluded that [[rs1800629]](A) carriers were associated with this type of [[hyperthyroidism]]. {{PMID|18472000}}

* [[Heart disease]]
** A study of 600 Italian patients concluded that [[rs1800629]](A) carriers are at increased risk for acute [[heart attack]] and have other markers of heart disease. The odd ratio was 1.86, CI: 1.08-3.21, p=0.027). {{PMID|16319659}}
** A study of 50 Egyptian children with [[rheumatic heart disease]] found increased risk associated with the [[rs1800629]](A;A) homozygotes, with odds ratio = 5.7, p<0.001. However, there was a significantly lower frequency of heterozygous genotypes.  {{PMID|17607501}}

* [[Leprosy]]
** A study of 37 Thai patients with [[leprosy]] found that the [[rs1800629]](A) allele was more common (odds ratio = 2.69, p=0.04). [PMID 17624216}

* Liver disease
** A study of 108 Chinese patients concludes that [[rs1800629]](A) carriers are at 3.23x (CI: 1.10-9.44) increased risk for [[liver cancer]] and are also at higher risk for [[hepatic fibrosis]] and more severe [[liver damage]]. {{PMID|18030367|OA=1
}} 

* [[Lymphoma]]
** A study of 194 Tunisian patients indicated an increased risk for [[non-Hodgkin lymphoma]] among [[rs1800629]](A;A) genotypes, at an odds ratio of 3.63, p=0.028. {{PMID|17087739}}
** A study of 441 incident [[non-Hodgkin lymphoma]] (NHL) cases indicated that, compared with the wild-type [[rs1800629]](G;G), the (A;A) genotype was associated with increased risk (odds ratio 2.14, CI: 0.94-4.85), whereas the (A;G) genotype was not. This association was similar for [[follicular lymphoma]] and [[diffuse large B-cell lymphoma]]. {{PMID|18990758|OA=1
}}
** A US study {{PMID|17018637}} of 1,172 [[lymphoma]] patients and 982 controls looked at 57 SNPs in 36 immune function genes. Five SNPs in two [[cytokine]] genes, [[tumor necrosis factor]]-alpha and lymphotoxin-alpha, were associated with a 1.31x increase in [[non-Hodgkin lymphoma]] (OR, 1.31; 95% CI, 1.06-1.63; P = 0.01) and with a 1.64x increase in the subtype known as [[diffuse large B cell lymphoma]] (OR, 1.64; 95% CI, 1.23-2.19; P = 0.0007). The other four SNPS are listed below. The cytokine genes affect inflammatory and innate immune responses.
*** [[rs361525]]
*** [[rs1799724]]
*** [[rs909253]]
*** [[rs2239704]]

* Susceptibility to [[Mediterranean spotted fever]]
** Although [[cytokine]] genes affect immune response to infection, in a Sicilian population the [[rs1800629]] polymorphism did not affect susceptibility to Mediterranean spotted fever. {{PMID|19386798|OA=1
}}

* [[Migraine]]
** Polymorphisms in the [[tumor necrosis factor]] (TNF) gene may be associated with migraine and cardiovascular disease. The [[rs1800629]] SNP has not been found significant. {{PMID|19559392|OA=1
}}

* [[Multiple sclerosis]] (MS)
** A study of 300 Croatian and Slovenian patients indicated that [[rs1800629]](A) carriers might be at lower risk for [[multiple sclerosis]]. {{PMID|17268200}}

* [[Nasal polyps]]
** The [[rs1800629]](A;G) genotype was associated with increased risk for [[nasal polyps]] in a study of 82 Turkish patients. {{PMID|17638785}} 
** Another study found a nearly doubled risk for [[rs1800629]](A) carriers (odds ratio, 1.86; confidence interval, 1.4-3.09). {{PMID|19405090|OA=1
}}

* [[Psoriasis]]
** A study of 160 Polish patients indicated that the [[rs1800629]](A) allele frequency was significantly decreased among patients with early-onset [[psoriasis]] (7.5% vs. 15.4%, p=0.022). {{PMID|17553030}}
** In contrast, 147 Irish patients with [[psoriasis]] were studied and the results indicated that the [[rs1800629]](A;A) genotype was associated with increased risk as well as earlier onset of [[psoriasis]]. {{PMID|12746914}}

* [[Rheumatoid arthritis]] - response to TNF-alpha inhibitors
** 2009 meta-analysis of 9 studies concludes [[rs1800629]](A) allele carriers respond less well to TNF-alpha inhibitors when being treated for [[rheumatoid arthritis]]. {{PMID|19365401}}

* [[Sarcoidosis]]
** In a pooled analysis of seven case-control studies, the odds ratio for [[sarcoidosis]] for carriers of the [[rs1800629]](A) allele was either 1.47 (CI 1.03-2.08 under a dominant model) or 1.39 (CI: 0.67-2.90; under a recessive model). {{PMID|17768594}}

* Susceptibility to [[sepsis]]
** A study of 159 patients with severe trauma indicated that the [[rs1800629]](A) allele was associated with higher risk of developing [[sepsis]] and of dying (odds ratio 7.65, two-sided p = 1.9 x 10<sup>-6</sup>). The authors of this research suggest that preemptive anti-inflammatory interventions should be developed for use in carriers of this SNP should they suffer severe injuries. {{PMID|18434886}}
** A meta-analysis of 25 studies concluded that while [[rs1800629]] status is significantly associated with risk for sepsis, especially among Asians, it was not associated with mortality from sepsis. However, there may be an increased risk for fatal outcomes among Asians (odds ratio 10.75, CI: 3-39, p < 0.01).{{PMID|19789454}}

* [[Systemic lupus erythematosus]] (SLE)
** A study of 120 Columbian patients with SLE found an increased risk for [[rs1800629]](A) carriers (odds ratio 3.9, CI: 1.65-5.80, p= 0.0004). {{PMID|17711410}}
** A meta-analysis of 21 studies indicated that in European populations, the [[rs1800629]](A) allele is associated with increased risk for [[systemic lupus erythematosus]] (SLE). In Europeans, the oodds ratio for the (A;A) genotype was 4.0, CI: 2.5-6.4, p<0.001. No association was detected in Asian-derived populations. The overall odds ratio for [[rs1800629]](A) carriers was 2.0 (CI: 1.3-3.1, p<0.001). {{PMID|16418737}}

{{PMID Auto
|PMID=19419979
|Title=Preliminary Evidence of a Genetic Association Between Tumor Necrosis Factor Alpha and the Severity of Sleep Disturbance and Morning Fatigue
}}
{{PMID Auto
|PMID=19654554
|Title=The Major Histocompatibility Complex Conserved Extended Haplotype 8.1 in AIDS-Related Non-Hodgkin Lymphoma
|OA=1
}}
{{PMID Auto
|PMID=19167443
|Title=Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia
|OA=1
}}

{{PharmGKB
|RSID=rs1800629
|Name_s=TNF:(-308)G>A, TNF2
|Gene_s=LTA, TNF
|Feature=Intron, Intron
|Evidence=PubMed ID:11294926
|Annotation=Risk or phenotype-associated allele: A . Phenotype: The TNF2 allele was associated with severe, but not nonserious, carbamazepine hypersensitivity reactions. Study size: 60 patients with carbamazepine hypersensitivity; 37 with nonserious reactions, 23 with serious reactions. Study population/ethnicity: Patients with carbamazepine hypersensitivity from the United Kingdom. Significance metric(s): p = 0.01; OR = 2.4. Type of association: CO; ADR.
|Drugs=carbamazepine
|Drug Classes=
|Diseases=Drug Hypersensitivity; Epidermal Necrolysis, Toxic; Epilepsy; Stevens-Johnson Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA165282093
}}

{{PMID Auto
|PMID=19233472
|Title=Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection
}}

{{PMID Auto
|PMID=20132806
|Title=Study of TNFalpha -308 G/A and IL6 -174 G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population
}}

{{PMID Auto
|PMID=20157068
|Title=Association of IL1A, IL1B, and TNF Gene Polymorphisms With Chronic Rhinosinusitis With and Without Nasal Polyposis: A Replication Study
}}
{{PMID Auto
|PMID=19773451
|Title=Role of inflammation gene polymorphisms on pain severity in lung cancer patients
|OA=1
}}
{{PMID Auto
|PMID=20177654
|Title=Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians
}}

{{PMID Auto
|PMID=20080841
|Title=Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components
}}
{{PMID Auto
|PMID=20357201
|Title=Association of Polymorphisms of Tumor Necrosis Factor and Tumor Protein p53 with Primary Open Angle Glaucoma: A Replication Study of Ten Genes in A Chinese Population
}}
{{PMID Auto
|PMID=20522203
|Title=Age- and gender-specific association between ADA (22G&gt;A) and TNF-alpha (-308G&gt;A) genetic polymorphisms
}}
{{PMID Auto
|PMID=20459604
|Title=Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes
|OA=1
}}
{{PMID Auto
|PMID=20578265
|Title=Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: Evidence for a gene-gene interaction
|OA=1
}}
{{PMID Auto
|PMID=20682333
|Title=Associations between the TNF-alpha gene (-308G--&gt;A) and event-related potential indices of attention and mental rotation
}}
{{PMID Auto
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|Title=Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma
}}
{{PMID Auto
|PMID=20946339
|Title=Association between the tumour necrosis factor-? -308G/A polymorphism and chronic obstructive pulmonary disease: An update
}}

{{PharmGKB
|RSID=rs1800629
|Name_s=TNF:-308G/A
|Gene_s=LTA, TNF
|Feature=Intron, Intron
|Evidence=PubMed ID:11857057; PubMed ID:11896460; PubMed ID:16476505; PubMed ID:17450233; PubMed ID:17562093
|Annotation=Well studied, contradictory reports on its effect on the rate of gene transcription and protein production of TNF. People carrying at least one copy of the TNF-308A allele was associated with increased asthma risk. The ?308 G/A was also suggested to be associated with the severity of rheumatoid arthritis.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145119
}}

{{PharmGKB
|RSID=rs1800629
|Name_s=TNF:-308G/A
|Gene_s=LTA, TNF
|Feature=Intron, Intron
|Evidence=PubMed ID:18716131
|Annotation=In a cohort of 780 children across a malaria season the TNF(-308) AA genotype was associated with an increased risk of iron deficiency and iron deficiency anemia at the end of the malaria season.
|Drugs=
|Drug Classes=
|Diseases=Anemia, Iron-Deficiency
|Curation Level=Curated
|PharmGKB Accession ID=PA162360114
}}

{{PharmGKB
|RSID=rs1800629
|Name_s=TNF:(-308)G>A; -308G>A
|Gene_s=LTA, TNF
|Feature=Intron, Intron
|Evidence=PubMed ID:17638513
|Annotation=The TNF:(-308)G>A polymorphism is a weak marker for response to anti-TNF treatment, with A-allele carriers being significantly less likely to respond than patients with the GG genotype.
|Drugs=adalimumab; etanercept; infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162652698
}}

{{PharmGKB
|RSID=rs1800629
|Name_s=TNF:-308 G/A
|Gene_s=LTA, TNF
|Feature=Intron, Intron
|Evidence=PubMed ID:19365401
|Annotation=The -308(A) variant may be a predictor for poor response to TNF-inhibitors.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA164892189
}}

{{PharmGKB
|RSID=rs1800629
|Name_s=TNF alpha -308G/A
|Gene_s=LTA, TNF
|Feature=Intron, Intron
|Evidence=PubMed ID:19773451
|Annotation=Risk or phenotype-associated allele: G. Phenotype: The GG genotype was associated with higher risk for severe pain. Study size: 667. Study population/ethnicity: Non-hispanic Caucasian patients with lung neoplasms, Texas; M. D. Anderson Cancer Center. Significance metric(s): OR = 1.67 (1.08-2.58); p = 0.02. Type of association: CO.
|Drugs=
|Drug Classes=
|Diseases=Pain
|Curation Level=Curated
|PharmGKB Accession ID=PA165349773
}}
{{PMID Auto
|PMID=21080879
|Title=A study of TNF-alpha-238 and -308 polymorphisms with different outcomes of persistent hepatitis B virus infection in China
}}
{{PMID Auto
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|Title=[Polymorphism of cytokine genes and human longevity]
}}
{{PMID Auto
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|Title=An association study of 21 potential Alzheimer's disease risk genes in a Finnish population
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{{PMID Auto
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{{PMID Auto
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}}

{{PMID Auto
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}}

{{PMID Auto
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|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
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}}

{{PMID Auto
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}}

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}}

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}}

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{{PMID Auto
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{{PMID Auto
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|Title=Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.
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}}

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}}

{{PMID Auto
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}}

{{PMID Auto
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{{PMID Auto
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}}

{{PMID Auto
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}}

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}}

{{PMID Auto
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|Title=Association between LTA, TNF and AGER polymorphisms and late diabetic complications.
|OA=1
}}

{{PMID Auto
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|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
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|Title=Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
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|Title=The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency.
|OA=1
}}

{{PMID Auto
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|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
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|Title=TNF promoter polymorphisms associated with muscle phenotypes in humans.
|OA=1
}}

{{PMID Auto
|PMID=18640487
|Title=Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18698679
|Title=Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk.
|OA=1
}}

{{PMID Auto
|PMID=18709160
|Title=Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.
|OA=1
}}

{{PMID Auto
|PMID=18713756
|Title=Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis.
}}

{{PMID Auto
|PMID=18715339
|Title=Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.
|OA=1
}}

{{PMID Auto
|PMID=18796628
|Title=Etiologic heterogeneity among non-Hodgkin lymphoma subtypes.
|OA=1
}}

{{PMID Auto
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|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
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|Title=Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma.
}}

{{PMID Auto
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|Title=Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
|PMID=19147066
|Title=Genomic and proteomic analysis of allogeneic hematopoietic cell transplant outcome. Seeking greater understanding the pathogenesis of GVHD and mortality.
|OA=1
}}

{{PMID Auto
|PMID=19225544
|Title=Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19281305
|Title=Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19347053
|Title=Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19401444
|Title=Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism.
|OA=1
}}

{{PMID Auto
|PMID=19409079
|Title=Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study.
|OA=1
}}

{{PMID Auto
|PMID=19438866
|Title=Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.
|OA=1
}}

{{PMID Auto
|PMID=19478423
|Title=Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels.
|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19615068
|Title=The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19661089
|Title=Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.
|OA=1
}}

{{PMID Auto
|PMID=19673019
|Title=IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.
|OA=1
}}

{{PMID Auto
|PMID=19700502
|Title=Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.
}}

{{PMID Auto
|PMID=19732761
|Title=Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease.
}}

{{PMID Auto
|PMID=19933216
|Title=The COPD genetic association compendium: a comprehensive online database of COPD genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=19934104
|Title=Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.
|OA=1
}}

{{PMID Auto
|PMID=20007930
|Title=A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.
|OA=1
}}

{{PMID Auto
|PMID=20031567
|Title=An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20047977
|Title=Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.
|OA=1
}}

{{PMID Auto
|PMID=20049212
|Title=Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).
|OA=1
}}

{{PMID Auto
|PMID=20113413
|Title=Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation.
}}

{{PMID Auto
|PMID=20206339
|Title=Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells.
}}

{{PMID Auto
|PMID=20361391
|Title=The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study.
}}

{{PMID Auto
|PMID=20396431
|Title=Genotyping sleep disorders patients.
|OA=1
}}

{{PMID Auto
|PMID=20401335
|Title=Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.
|OA=1
}}

{{PMID Auto
|PMID=20463618
|Title=Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
|OA=1
}}

{{PMID Auto
|PMID=20565774
|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{PMID Auto
|PMID=20668555
|Title=Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.
|OA=1
}}

{{PMID Auto
|PMID=20725607
|Title=CCL3 genotype and current depression increase risk of HIV-associated dementia.
|OA=1
}}

{{PMID Auto
|PMID=20796230
|Title=Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus.
}}

{{PMID Auto
|PMID=20810691
|Title=Variations in the TNF-alpha gene (TNF-alpha -308G-->A) affect attention and action selection mechanisms in a dissociated fashion.
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=20878356
|Title=Role of ethnic variations in TNF-alpha and TNF-beta polymorphisms and risk of breast cancer in India.
}}

{{PMID Auto
|PMID=21320344
|Title=Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
|OA=1
}}

{{PMID Auto
|PMID=21385363
|Title=Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=21420089
|Title=TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis.
}}

{{PMID Auto
|PMID=21448414
|Title=Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.
|OA=1
}}

{{PMID Auto
|PMID=21621860
|Title=Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-alpha polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.
}}

{{PMID Auto
|PMID=21670964
|Title=Association between TNF-alpha polymorphisms and cervical cancer risk: a meta-analysis.
}}

{{PMID Auto
|PMID=21735105
|Title=TNF-308 gene polymorphism and tuberculosis susceptibility: a meta-analysis involving 18 studies.
}}

{{PMID Auto
|PMID=21846573
|Title=Association between genetic risk score and periodontitis onset and progression: a pilot study.
}}

{{PMID Auto
|PMID=21880580
|Title=Interaction between functional polymorphic variants in cytokine genes, established risk factors and susceptibility to basal cell carcinoma of skin.
}}

{{PMID Auto
|PMID=21967963
|Title=TNF-alpha -308 G>A polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment.
}}

{{PMID Auto
|PMID=22070425
|Title=Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.
}}

{{PMID Auto
|PMID=22372709
|Title=Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.
}}

{{PMID Auto
|PMID=22376040
|Title=Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
}}

{{PMID Auto
|PMID=22684480
|Title=Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFalpha
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{{PMID Auto
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|Title=Genetic Variation in the TNF Gene Is Associated with Susceptibility to Severe Sepsis, but Not with Mortality
|OA=1
}}

{{PMID Auto
|PMID=23072573
|Title=Multiplex Allele-Specific Amplification from Whole Blood for Detecting Multiple Polymorphisms Simultaneously
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800629
|overall_frequency_n=638
|overall_frequency_d=4534
|overall_frequency=0.140715
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=12
|n_articles=5
|n_articles_annotated=2
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23241556
|Title=Haplotype of Single Nucleotide Polymorphisms in Exon 6 of the MZF-1 Gene and Alzheimer's Disease
}}

{{PMID Auto
|PMID=23487197
|Title=Association of Interleukin 2 (IL-2), Interleukin 6 (IL-6), and TNF-alpha (TNFα) Gene Polymorphisms With Paranoid Schizophrenia in a Polish Population
}}

{{PMID Auto
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|Title=Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer
}}

{{PMID Auto
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|Title=Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes
|OA=1
}}

{{PMID Auto
|PMID=23870134
|Title=Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma
|OA=1
}}

{{PMID Auto
|PMID=23906902
|Title=Tumor necrosis factor-308 polymorphism increases the embryo implantation rate in women undergoing in vitro fertilization
}}

{{PMID Auto
|PMID=23919499
|Title=Associations between tumor necrosis factor-alpha gene -238 G/A and -308 G/A polymorphisms and the risk of pneumoconiosis: update of a meta-analysis
}}

{{PMID Auto
|PMID=23267696
|Title=Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study
|OA=1
}}

{{PMID Auto
|PMID=23961418
|Title=Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians
|OA=1
}}

{{PMID Auto
|PMID=24037955
|Title=The presence of prostate cancer at biopsy is predicted by a number of genetic variants
}}

{{PMID Auto
|PMID=24072494
|Title=Quantitative assessment of the influence of tumor necrosis factor alpha polymorphism with gastritis and gastric cancer risk
}}

{{PMID Auto
|PMID=23639307
|Title=Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study
}}

{{PMID Auto
|PMID=24151497
|Title=Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria
|OA=1
}}

{{PMID Auto
|PMID=23380141
|Title=Association of HLA-DRB1 and TNF genotypes with dengue hemorrhagic fever
}}

{{PMID Auto
|PMID=24160187
|Title=Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA
|OA=1
}}

{{PMID Auto
|PMID=24252077
|Title=Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis
}}

{{PMID Auto
|PMID=24359571
|Title=The impact of genetic variants in inflammatory-related genes on prostate cancer risk among men of African Descent: a case control study
|OA=1
}}

{{PMID Auto
|PMID=24385694
|Title=Effect of cytotoxic T-lymphocyte antigen-4, TNF-alpha polymorphisms on osteosarcoma: evidences from a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=24465030
|Title=GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study
|OA=1
}}

{{PMID Auto
|PMID=22579472
|Title=The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
}}

{{PMID Auto
|PMID=22649007
|Title=Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=22711844
|Title=SNPs in the TNF-alpha gene promoter associated with Behcet's disease in Moroccan patients.
}}

{{PMID Auto
|PMID=22749237
|Title=Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.
|OA=1
}}

{{PMID Auto
|PMID=22897480
|Title=Investigation of selected cytokine genes suggests that IL2RA and the TNF/LTA locus are risk factors for severe alopecia areata.
}}

{{PMID Auto
|PMID=22925444
|Title=Genetic and immunological markers predict titanium implant failure: a retrospective study.
}}

{{PMID Auto
|PMID=23011034
|Title=Effect of the polymorphisms of tumor necrosis factor-alpha gene on the susceptibility to primary biliary cirrhosis: a meta-analysis.
}}

{{PMID Auto
|PMID=23029430
|Title=Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
|OA=1
}}

{{PMID Auto
|PMID=23053960
|Title=Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
}}

{{PMID Auto
|PMID=23107763
|Title=Host genetic risk factors for community-acquired pneumonia.
}}

{{PMID Auto
|PMID=23159874
|Title=Pro-inflammatory cytokine gene polymorphisms and threat for coronary heart disease in a North Indian Agrawal population.
}}

{{PMID Auto
|PMID=23294973
|Title=Association of TNF-alpha polymorphism rs1800629 with multisomatoform disorder in a group of German patients and healthy controls: an explorative study.
}}

{{PMID Auto
|PMID=23357300
|Title=Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.
}}

{{PMID Auto
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|Title=Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab.
}}

{{PMID Auto
|PMID=23438931
|Title=Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension.
}}

{{PMID Auto
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|Title=Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=23530106
|Title=Cytokine genetic variations and fatigue among patients with breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=23590430
|Title=Genetic polymorphisms of tumour necrosis factor alpha (TNF-alpha) promoter gene and response to TNF-alpha inhibitors in Spanish patients with inflammatory bowel disease.
}}

{{PMID Auto
|PMID=23640160
|Title=IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.
}}

{{PMID Auto
|PMID=23748461
|Title=Association analysis of two candidate polymorphisms in the tumour necrosis factor-alpha gene with osteoarthritis in a Chinese population.
}}

{{PMID Auto
|PMID=23796916
|Title=Tumor necrosis factor alpha promoter polymorphism and severity of acute kidney injury.
}}

{{PMID Auto
|PMID=24798719
|Title=TNF-α SNP rs1800629 and risk of relapse in childhood acute lymphoblastic leukemia: relation to immunophenotype
}}

{{PMID Auto
|PMID=24008079
|Title=Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts
}}

{{PMID Auto
|PMID=24905365
|Title=TNF-α gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies
}}

{{PMID Auto
|PMID=24935328
|Title=Functional tumor necrosis factor alpha polymorphisms and haplotype analysis in high-risk corneal transplantation
}}

{{PMID Auto
|PMID=24935327
|Title=Haplotype Analysis on Chromosome 6p of Tumor Necrosis Factor Alpha, Vascular Endothelial Growth Factor A, and Interleukin-17F Alleles Associated With Corneal Transplant Rejection
}}

{{PMID Auto
|PMID=24971461
|Title=Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
}}

{{PMID Auto
|PMID=25010932
|Title=Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women
}}

{{PMID Auto
|PMID=25054016
|Title=Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies
}}

{{PMID Auto
|PMID=25127106
|Title=Polymorphisms in the TNFA and IL6 Genes Represent Risk Factors for Autoimmune Thyroid Disease
}}

{{PMID Auto
|PMID=25175451
|Title=The functional VNTR of IGH enhancer HS1.2 associates with human longevity and interacts with TNFA promoter diplotype in a population of Central Italy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}