{{Rsnum
|rsid=1800630
|Gene=LTA
|Chromosome=6
|position=31574699
|Orientation=plus
|GMAF=0.1451
|Gene_s=LTA,TNF
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 30.1 | 69.9
| HCB | 2.2 | 28.5 | 69.3
| JPT | 0.9 | 20.4 | 78.8
| YRI | 1.4 | 16.3 | 82.3
| ASW | 0.0 | 21.1 | 78.9
| CHB | 2.2 | 28.5 | 69.3
| CHD | 3.7 | 32.1 | 64.2
| GIH | 5.0 | 34.7 | 60.4
| LWK | 1.8 | 22.7 | 75.5
| MEX | 3.4 | 24.1 | 72.4
| MKK | 0.0 | 10.9 | 89.1
| TSI | 2.0 | 29.4 | 68.6
| HapMapRevision=28
}}
[[rs1800630]] is a SNP upstream of the tumor necrosis alpha (TNF) gene; this SNP is also typically called the -863 variant.

In a study of 154 Thai patients with systemic [[lupus]] erythematosus (SLE), [[rs1800630]](A) allele frequency was significantly increased, with an odds ratio of 1.85 (CI: 1.21-2.83, p(corr) = 0.009). This allele was also found to be significantly increased in the SLE group with Raynaud's phenomenon compared to SLE without Raynaud's phenomenon ( odds ratio of 2.23, CI: 1.21-4.10, p(corr) = 0.048).{{PMID|18001298}}

Separately, a meta-analysis of 10 case-control studies, including over 2,200 [[Graves' disease]] cases, concluded that [[rs1800630]](A) carriers were associated with the disease.{{PMID|18472000}}

{{ neighbor
| rsid = 1799964
| distance = 168
}}
{{ neighbor
| rsid = 1799724
| distance = 6
}}

{{PMID Auto
|PMID=20177654
|Title=Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians
}}

{{PMID Auto
|PMID=20825556
|Title=Tumour necrosis factor-Î± promoter region polymorphisms affect the course of spontaneous HBsAg clearance
}}

{{PMID Auto
|PMID=21450487
|Title=Tumor necrosis factor-? -863 C/A promoter polymorphism affects the inflammatory response after cardiac surgery
}}

{{PMID Auto
|PMID=21904873
|Title=Association of tumor necrosis factor-? (TNF-?) promoter polymorphisms with overweight/obesity in a Korean population
}}

{{PMID Auto
|PMID=21985478
|Title=TNFA -863 polymorphism is associated with a reduced risk of Chronic Obstructive Pulmonary Disease: A replication study
|OA=1
}}

{{PMID Auto
|PMID=21593777
|Title=Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population.
}}

{{PMID Auto
|PMID=12509789
|Title=Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=17216494
|Title=Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17493155
|Title=Significant association between TNF-alpha (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand.
}}

{{PMID Auto
|PMID=17595314
|Title=Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample.
}}

{{PMID Auto
|PMID=18194515
|Title=Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population.
|OA=1
}}

{{PMID Auto
|PMID=18196539
|Title=TNF polymorphisms and prostate cancer risk.
}}

{{PMID Auto
|PMID=18366708
|Title=SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18635873
|Title=TNF promoter polymorphisms associated with muscle phenotypes in humans.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18709160
|Title=Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19409079
|Title=Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study.
|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19615068
|Title=The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19673019
|Title=IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.
|OA=1
}}

{{PMID Auto
|PMID=19673882
|Title=A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.
|OA=1
}}

{{PMID Auto
|PMID=20217072
|Title=SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.
|OA=1
}}

{{PMID Auto
|PMID=20796230
|Title=Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus.
}}

{{PMID Auto
|PMID=21385363
|Title=Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=23870134
|Title=Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma
|OA=1
}}

{{PMID Auto
|PMID=24151497
|Title=Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria
|OA=1
}}

{{PMID Auto
|PMID=24405540
|Title=[Association of TNF-1031T/C and clinical efficacy of insulin therapy in newly diagnosed type 2 diabetics]
}}

{{PMID Auto
|PMID=22711844
|Title=SNPs in the TNF-alpha gene promoter associated with Behcet's disease in Moroccan patients.
}}

{{PMID Auto
|PMID=24905365
|Title=TNF-α gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies
}}

{{PMID Auto
|PMID=24935328
|Title=Functional tumor necrosis factor alpha polymorphisms and haplotype analysis in high-risk corneal transplantation
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}