{{Rsnum
|rsid=1800693
|Gene=TNFRSF1A
|Chromosome=12
|position=6330843
|Orientation=plus
|GMAF=0.3173
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TNFRSF1A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 28.3 | 46.9 | 24.8
| HCB | 79.6 | 19.7 | 0.7
| JPT | 65.5 | 31.9 | 2.7
| YRI | 46.3 | 42.2 | 11.6
| ASW | 42.1 | 45.6 | 12.3
| CHB | 79.6 | 19.7 | 0.7
| CHD | 78.9 | 19.3 | 1.8
| GIH | 45.5 | 40.6 | 13.9
| LWK | 37.3 | 48.2 | 14.5
| MEX | 50.0 | 39.7 | 10.3
| MKK | 42.3 | 46.2 | 11.5
| TSI | 36.3 | 44.1 | 19.6
| HapMapRevision=28
}}[[rs1800693]] is a SNP in the tumor necrosis factor receptor superfamily, member 1A [[TNFRSF1A]] gene.

A large study (~5,000 patients) found two SNPs in the [[TNFRSF1A]] gene that each (independently) increase risk for [[multiple sclerosis]], [[rs1800693]] and [[rs4149584]]. This SNP, [[rs1800693]], is more common but increases risk less; the odds ratio is reported as 1.2 (CI: 1.10-1.31, p=1.6x10(-11)). {{PMID|19525953|OA=1
}} {{doi|10.1038/ng.401}}

{{PMID Auto GWAS
|PMID=19525953
|Trait=Multiple sclerosis
|Title=Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
|RiskAllele=C
|Pval=2E-11
|OR=1.20
|ORtxt=[1.10-1.31]
|OA=1
}}

{{omim
|id=126200
|rsnum=1800693
}}

{{PMID Auto GWAS
|PMID=21399635
|Trait=None
|Title=Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
|RiskAllele=C
|Pval=2E-9
|OR=1.2200
|ORtxt=[1.14-1.30]
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=20217072
|Title=SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.
|OA=1
}}

{{PMID Auto
|PMID=20405052
|Title=The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
|OA=1
}}

{{PMID Auto
|PMID=22994200
|Title=Associations of CD6, TNFRSF1A, and IRF8 polymorphisms with risk of inflammatory demyelinating diseases
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800693
|overall_frequency_n=4184
|overall_frequency_d=10758
|overall_frequency=0.38892
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=21833088
  |Trait=Multiple sclerosis
  |Title=Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
  |RiskAllele=G
  |Pval=4E-14
  |OR=1.12
  |ORtxt=[1.11-1.14]
  |OA=1
}}

{{PMID Auto
|PMID=23624563
|Title=TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis.
}}

{{PMID Auto
|PMID=24790215
|Title=Stimulated PBMC-produced IFN-γ and TNF-α are associated with altered relapse risk in multiple sclerosis: results from a prospective cohort study
}}

{{PMID Auto
|PMID=25010932
|Title=Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}