{{Rsnum
|rsid=1800759
|Gene=ADH4
|Chromosome=4
|position=99144358
|Orientation=minus
|GMAF=0.4605
|Gene_s=SLC3A1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 14.2 | 47.8 | 38.1
| HCB | 5.9 | 32.4 | 61.8
| JPT | 0.9 | 32.1 | 67.0
| YRI | 74.8 | 25.2 | 0.0
| ASW | 58.9 | 39.3 | 1.8
| CHB | 5.9 | 32.4 | 61.8
| CHD | 1.8 | 18.3 | 79.8
| GIH | 0.0 | 21.0 | 79.0
| LWK | 66.1 | 31.2 | 2.8
| MEX | 27.6 | 58.6 | 13.8
| MKK | 53.8 | 35.9 | 10.3
| TSI | 17.6 | 48.0 | 34.3
| HapMapRevision=28
}}[[rs1800759]] is a SNP in the promoter (regulatory region) of the alcohol dehydrogenase 4 ([[ADH4]]) gene.

In a study of 500+ patients with either [[alcohol dependence]] or [[drug dependence]], [[rs1800759]] was the most significant [[ADH4]] SNP to be associated (in a recessive manner) with increased risk for either condition, at least in Caucasians.{{PMID|16237392}}

In another study, a five-factor model of [[personality traits |personality]] in 243 subjects with substance dependence (175 European Americans [EAs] and 68 African Americans [AAs]), along with 296 healthy control subjects (256 EAs and 40 AAs), was conducted in association with an [[ADH4]] SNP survey. [[rs1800759]](A) alleles and (A;A) genotypes A/A were significantly associated with agreeableness scores.{{PMID|17069770|OA=1
}}

{{PMID Auto
|PMID=19925625
|Title=Cluster Headache is Associated With the Alcohol Dehydrogenase 4 (ADH4) Gene
}}

{{PMID Auto
|PMID=20626721
|Title=Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study
}}

{{PMID Auto
|PMID=22232963
|Title=[Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]
}}

{{PMID Auto
|PMID=16685648
|Title=Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
|OA=1
}}

{{PMID Auto
|PMID=17185388
|Title=Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.
|OA=1
}}

{{PMID Auto
|PMID=17273965
|Title=Evidence of positive selection on a class I ADH locus.
|OA=1
}}

{{PMID Auto
|PMID=18801187
|Title=Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test.
|OA=1
}}

{{PMID Auto
|PMID=18996923
|Title=Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.
|OA=1
}}

{{PMID Auto
|PMID=19193628
|Title=ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}