{{Rsnum
|rsid=1800779
|Gene=NOS3
|Chromosome=7
|position=150992855
|Orientation=plus
|GMAF=0.2502
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NOS3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 36.9 | 46.8 | 16.2
| HCB | 76.9 | 23.1 | 0.0
| JPT | 80.4 | 19.6 | 0.0
| YRI | 78.8 | 21.2 | 0.0
| ASW | 73.7 | 24.6 | 1.8
| CHB | 76.9 | 23.1 | 0.0
| CHD | 78.9 | 18.3 | 2.8
| GIH | 64.4 | 28.7 | 6.9
| LWK | 75.2 | 22.0 | 2.8
| MEX | 61.4 | 29.8 | 8.8
| MKK | 64.3 | 32.5 | 3.2
| TSI | 24.5 | 56.9 | 18.6
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19815736
|Title=The Relation between Endothelial Nitric Oxide Synthase Gene Variants and Primary Open-Angle Glaucoma: Interactions with Gender and Postmenopausal Hormone Use
|OA=1
}}

{{PharmGKB
|RSID=rs1800779
|Name_s=NOS3:(-922)G>A, NOS3 -922 G>A
|Gene_s=NOS3
|Feature=Intron
|Evidence=PubMed ID:16100023
|Annotation=Risk or phenotype-associated variant: A. Phenotype: The NOS3:(-922)A allele was more prevalent in cases than controls. It was also in strong linkage with NOS3:(-786)T. Study size: 124. Study population/ethnicity: Black women in the Stroke Prevention in Young Women case-control study. Significance metric(s): OR=3.0; 95% CI=1.3 to 6.8; p = 0.005. Type of association: CO.
|Drugs=
|Drug Classes=
|Diseases=Stroke
|Curation Level=Curated
|PharmGKB Accession ID=PA165110260
}}

{{PMID Auto
|PMID=20409549
|Title=NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids
}}
{{PMID Auto
|PMID=21122033
|Title=Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients
}}

{{PMID Auto
|PMID=21291465
|Title=The association of genetic polymorphisms with cerebral palsy: a meta-analysis
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=18069999
|Title=Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study.
}}

{{PMID Auto
|PMID=18246059
|Title=Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=18687083
|Title=Lack of association of endothelial nitric oxide synthase polymorphisms and migraine.
}}

{{PMID Auto
|PMID=18698212
|Title=Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19493349
|Title=118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19584173
|Title=Kininogen gene (KNG) variation has a consistent effect on aldosterone response to antihypertensive drug therapy: the GERA study.
|OA=1
}}

{{PMID Auto
|PMID=20031567
|Title=An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=21674837
|Title=Association of NOS3 tag polymorphisms with hypoxic-ischemic encephalopathy.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1800779
|overall_frequency_n=96
|overall_frequency_d=128
|overall_frequency=0.75
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=82
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24192154
|Title=Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease
|OA=1
}}

{{PMID Auto
|PMID=23826716
|Title=Association analysis of nitric oxide synthases: NOS1, NOS2A and NOS3 genes, with multiple sclerosis.
}}

{{PMID Auto
|PMID=25140814
|Title=Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}